Page 52 - IJB-10-2

International

Journal of Bioprinting

REVIEW ARTICLE
Recent developments and challenges of 3D

bioprinting technologies

Ximin Yuan , Zhenjia Wang , Lixin Che , Xushuai Lv , Jie Xu *,
1,2
1,2
3
1,2
1,2
Debin Shan , and Bin Guo *
1,2
1,2
1 State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin,
Heilongjiang, China
2 National Innovation Center for Advanced Medical Devices, Shenzhen, Guangdong, China
3 Dalian Jiang Xiaolan Dental Clinic Co., Ltd, Dalian, Liaoning, China
(This article belongs to the Special Issue: Advances in Bioprinting Technologies)
Abstract
Three-dimensional (3D) bioprinting technologies play significant roles in various
facets of the medical field, such as bioengineering, tissue repair, scaffolds,
biomedical devices, and drug. As a versatile manufacturing technology, 3D
bioprinting is able to overcome the constraints of other conventional methods
and shows potential for future advancements in the field of biology. Nevertheless,
the existing 3D bioprinting technologies still grapple with significant challenges in
materials, equipment, and applications. Therefore, it is essential to select appropriate
bioprinting method in alignment with the required application. In this review, we
aim to cover the development, classification, and application of 3D bioprinting,
with a particular emphasis on the fundamental printing principles. Additionally, we
discuss the potential of 3D bioprinting in terms of materialization, structuralization,
*Corresponding authors: and functionalization, highlighting its prospective applications. We firmly believe
Jie Xu that 3D printing technology will witness widespread adoption in the future, as it has
(xjhit@hit.edu.cn) the potential to address the limitations associated with multi-size, multi-material,
Bin Guo
(bguo@hit.edu.cn) multi-cell, and high-precision bioprinting.
Citation: Yuan X, Wang Z, Che L,
et al. Recent developments Keywords: Tissue engineering; Scaffolds; Biomedical devices; Drug delivery
and challenges of 3D bioprint-
ing technologies. Int J Bioprint.
2024;10(2):1752.
doi: 10.36922/ijb.1752
Received: September 3, 2023 1. Introduction
Accepted: October 30, 2023
Published Online: January 27, 2024 Three-dimensional (3D) bioprinting technology leverages customizable 3D models,
software algorithms, and precision control molding methods to integrate cells,
Copyright: © 2024 Author(s). biomolecules, and biological scaffolds. This innovative and multidisciplinary field
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This is an Open Access article
distributed under the terms of the unifies manufacturing principles with biomedical science to conceive and produce
Creative Commons Attribution functional artificial organs, implants, and intricate 3D cellular structures. Due to their
2
License, permitting distribution, capacity to fabricate intricate and personalized structures, 3D bioprinting technologies
and reproduction in any medium,
provided the original work is hold tremendous potential in medical applications. More importantly, 3D printing offers
properly cited. an effective solution, marked by its precision and customization capabilities, to address
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Publisher’s Note: AccScience the distinct physiological variations and characteristics between individuals. Thus, this
Publishing remains neutral with technology finds utility in crafting medical innovations like customized implant stents,
regard to jurisdictional claims in tissues, and organs, which can be tailored to individual needs, revolutionizing healthcare
published maps and institutional
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affiliations. through personalized therapeutic solutions. 3D bioprinting demonstrates its prowess
Volume 10 Issue 2 (2024) 44 doi: 10.36922/ijb.1752