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Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation

Figure 2. Fourier transform infrared spectra of matrix-assisted pulsed laser evaporation-deposited coatings on glass. Figure (a) shows the
spectrum for deposition with the AmfB(260) target (amphotericin B 1040 mg/mL + 1% polyvinylpyrrolidone) and Figure (b) shows the
spectrum for deposition with the AmfB(520) target (amphotericin B 2080 mg/mL + 1% polyvinylpyrrolidone).

deposition with the AmfB(520) target (amphotericin B microneedles showed higher surface roughness than the
2080 mg/mL + 1% polyvinylpyrrolidone), respectively. unmodified polyglycolic acid microneedle.
In previous studies, Boehm et al. used the drawing Figure 4(a) shows a 3D representation of an uncoated
lithography process to create sharpened polyglycolic polyglycolic acid microneedle, Figure 4(b) shows a
acid microneedles for tissue penetration [12,13] . As seen 3D representation of a matrix-assisted pulsed laser
in Figure 3(a–c), all of the microneedles created using evaporation-coated microneedle from deposition with
the combination of injection molding and drawing the AmfB(260) target (amphotericin B 1040 mg/mL
lithography taper from the base, narrow toward the tip, + 1% polyvinylpyrrolidone), and Figure 4(c) shows
and come to a point at the tip. In addition, the images of a 3D representation of a matrix-assisted pulsed laser
the matrix-assisted pulsed laser evaporation-modified evaporation-coated microneedle from deposition

152 International Journal of Bioprinting (2017)–Volume 3, Issue 2