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International Journal of Bioprinting                              3D bioscaffolds with SR1 for vasculogenesis




            5. Conclusion                                      Availability of data
            Through the sustained release of SR1, 3D-printed scaffolds   Data used in this work are available from the corresponding
            successfully promoted angiogenesis and bone regeneration.   author upon reasonable request.
            In vitro  studies showed  that  SR1-loaded  MSNs  released
            SR1 sustainably, which led not only to the expansion of   References
                 +
            CD34  cell populations, but also promoted the migration
            and angiogenic differentiation of ECs. In animal studies,   1.   Roberts TT, Rosenbaum AJ. Bone grafts, bone substitutes
            sustained topical release of SR1 increased vasculogenesis   and orthobiologics: the bridge between basic science and
            at the defect site. With an increased blood supply through   clinical advancements in fracture healing.  Organogenesis.
            the regenerated vessels, spontaneous bone healing could      2012;8(4):114-124.
                                                                  doi: 10.4161/org.23306
            be  promoted.  Overall,  SR1  loaded  in  3D-printed  bone
            scaffolds can promote angiogenesis in vivo.        2.   Zhang L, Yang G, Johnson BN, Jia  X. Three-dimensional
                                                                  (3D) printed scaffold and material selection for bone repair.
            Acknowledgments                                       Acta Biomater. 2019;84:16-33.
                                                                  doi: 10.1016/j.actbio.2018.11.039
            None.
                                                               3.   Wang H, Su K, Su L, Liang P, Ji P, Wang C. The effect of 3D-printed
                                                                  Ti(6)Al(4)V scaffolds with various macropore structures on
            Funding                                               osteointegration and osteogenesis: a biomechanical evaluation.
            This work was supported by a grant from the National   J Mech Behav Biomed Mater. 2018;88:488-496.
            Research Foundation (NRF2020R1A2C2101297 and          doi: 10.1016/j.jmbbm.2018.08.049
            2022R1A5A2027161) funded by the Korean government,   4.   Pei X, Ma L, Zhang B, et al. Creating hierarchical
            the Korea Medical Device Development Fund grant       porosity hydroxyapatite  scaffolds  with  osteoinduction
            funded by the Korea government (the Ministry of Science   by three-dimensional printing and microwave sintering.
            and ICT, the Ministry of Trade, Industry and Energy, the   Biofabrication. 2017;9(4):045008.
            Ministry of Health & Welfare, the Ministry of Food and      doi: 10.1088/1758-5090/aa90ed
            Drug Safety) (Project number: 1711179402, RS-2022-  5.   Dadhich P, Das B, Pal P, et al. A simple approach for an
            00140622), and South Korean Ministry of Trade, Industry,   eggshell-based 3D-printed osteoinductive multiphasic
            and Energy via the 2021 Outstanding Company Research   calcium phosphate scaffold.  ACS Appl Mater Interfaces.
            Center Promotion Project (ATC+).                      2016;8(19):11910-11924.
                                                                  doi: 10.1021/acsami.5b11981
            Conflict of interest                               6.   Raisian S, Fallahi HR, Khiabani KS, Heidarizadeh M, Azdoo
                                                                  S. Customized titanium mesh based on the 3D printed
            The authors declare no conflicts of interest.         model vs. manual intraoperative bending of titanium mesh
                                                                  for reconstructing of orbital bone fracture: a randomized
            Author contributions                                  clinical trial. Rev Recent Clin Trials. 2017;12(3):154-158.
            Conceptualization:  KyeongWoong Yang, Sang-Mo Kwon,      doi: 10.2174/1574887112666170821165206
               SangHyun An                                     7.   Kuttappan S, Mathew D, Jo JI, et al. Dual release of growth
            Formal analysis: KyeongWoong Yang, Eun Ji Lee, Donggu   factor from nanocomposite fibrous scaffold promotes
               Kang, KyeongHyeon Lee                              vascularisation and bone regeneration in rat critical sized
            Investigation: KyeongWoong Yang, Kyoung Ho Lee, Woong   calvarial defect. Acta Biomater. 2018;78:36-47.
               Bi Jang                                            doi: 10.1016/j.actbio.2018.07.050
            Methodology: KyeongWoong Yang, Donghyun Lee, Hye Ji   8.   Rouwkema J, Rivron NC, van Blitterswijk CA.
               Lim, Sang-Cheol Han, Yong-Il Shin                  Vascularization in tissue engineering.  Trends  Biotechonol.
            Writing – original draft: KyeongWoong Yang            2008;26(8):434-441.
            Writing – review & editing: Hojun Jeon, Gi Hoon Yang     doi: 10.1016/j.tibtech.2008.04.009
                                                               9.   Urbich C, Dimmeler S. Endothelial progenitor cells:
            Ethics approval and consent to participate            characterization and role in vacular biology.  Circ Res.
                                                                  2004;95(4):343-353.
            Animal experiments were approved by the local animal ethics      doi: 10.1161/01.RES.0000137877.89448.78
            committee (approval number: KMEDI-22080801-01).
                                                               10.  Asahara T, Murohara T, Sullivan A, et al. Isolation of putative
            Consent for publication                               progenitor endothelial cells for angiogenesis.  Science.
                                                                  1997;275(5302):964-967.
            Not applicable.                                       doi: 10.1126/science.275.5302.964

            Volume 10 Issue 3 (2024)                       274                                doi: 10.36922/ijb.1931
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