Page 489 - IJB-10-3

International Journal of Bioprinting Stretchable scaffold for modeling fibrosis

Figure 9. Stiffness and stress testing of the PCL scaffolds: (A) PCL scaffold stress-strain curve; (B) Young’s modulus of PCL scaffolds with a different number
of layers, calculated by tensile tests (****p < 0.0001); (C) stiffness of PCL scaffolds with a different number of layers, calculated by S-L.B. approximation,
FEM analysis, and tensile tests; (D) cyclic stress-strain curves for PCL (blue), PCL/GelMA_5 (red), PCL/GelMA_7 (grey), and PCL/GelMA_10 (yellow)
scaffolds (n = 3). Abbreviations: FEM: Finite element method; ns: Non-significant; PCL: Poly(ε-caprolactone); PCL/GelMA: Poly(ε-caprolactone)-gelatin
methacryloyl; S-L.B: Straight-line beam.

Table 3. Stiffness and Young’s modulus values of PCL/GelMA scaffolds derived from uniaxial tensile tests in wet condition
Number of layers Bioartificial scaffold Tensile test
Stiffness (N/mm) Young’s modulus (MPa)
4 PCL/GelMA_5
0.51 ± 0.01 6.76 ± 0.18
PCL/GelMA_7
0.56 ± 0.01 7.66 ± 0.18
PCL/GelMA_10
0.65 ± 0.10 9.47 ± 1.39
8 PCL/GelMA_5
0.85 ± 0.07 8.21 ± 0.68
PCL/GelMA_7
0.96 ± 0.03 8.88 ± 0.26
PCL/GelMA_10
1.18 ± 0.01 10.46 ± 0.03
Abbreviation: PCL/GelMA: poly(ε-caprolactone)-gelatin methacryloyl.

Volume 10 Issue 3 (2024) 481 doi: 10.36922/ijb.2247