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International Journal of Bioprinting                                Mechanical responses of 3D-printed AFO




               Overall, the minimal impact of inferior trim depth   opportunities for standardization and expanded design
            on AFO stiffness suggested that alterations in the inferior   possibilities, though decision-making becomes more
            direction may not be as critical in influencing the overall   complex. By bridging the gap between empirical design
            mechanical response of AFOs. Clinicians may find   and technological advancements,  the findings  of this
            reassurance in maintaining flexibility in choosing inferior   study can offer insights into the development and
            trim depths within a certain range without significantly   customization of 3D-printed AFOs for individuals with
            compromising stiffness. On the other hand, the notable   specific conditions.
            changes observed in DF and PF stiffness with variations
            in posterior trim depth highlight the importance of this   Acknowledgments
            parameter in determining the overall rigidity of AFOs. The   This research was supported by The Lorenzo and Pamela
            substantial decrease in stress concentration around the
            ankle region with higher posterior trim depth suggested   Galli Medical Research Trust. The authors would like to
            a potential enhancement in the overall comfort of AFOs.   thank  Prof.  Kerr  Graham  for  reviewing  and  editing the
            This reduction in stress concentration could be particularly   manuscript.
            beneficial in mitigating  discomfort or pressure points
            around the ankle, enhancing its wearability, and minimizing   Funding
            the risk of adverse effects on the skin and soft tissues.   None.
            Meanwhile, the reduction of stress concentrations may also
            be beneficial to prevent potential fatigue failure of AFOs.   Conflict of interest

            4. Conclusion                                      The authors declare no conflicts of interest.

            The present study was designed to investigate the impact   Author contributions
            of base materials, thickness, and trimline variations
            on the stiffness and deformation of 3D-printed AFOs   Conceptualization: Chenxi Peng, Phuong Tran, Erich Rutz
            through a comprehensive parametric study based on   Formal analysis: Chenxi Peng
            numerical  modeling.  Firstly,  the  anatomical  geometry   Investigation: Chenxi Peng, Phuong Tran, Simon Lalor
            of the foot and leg was established using a 3D-scanning   Methodology: Chenxi Peng, Erich Rutz
            system and reconstructed into a smooth surface     Supervision: Erich Rutz
            representation. Subsequently, a baseline AFO design   Writing – original draft: Chenxi Peng
            was created, 3D printed, and subjected to testing under   Writing  –  review  &  editing: Phuong Tran, Simon Lalor,
            uniaxial compression. An FE model was developed       Oren Tirosh, Erich Rutz
            and validated using experimental data. The mechanical
            properties of PCTG, PA12, PA12-CF, and PLA were    Ethics approval and consent to participate
            characterized through tensile tests. A parametric study   Not applicable.
            on the effects of base materials, thickness, and trimline
            location was conducted.                            Consent for publication
               The results indicated that AFOs responded differently to   Not applicable.
            PF and DF stress, displaying a linear moment–ankle angle
            relationship in PF and a nonlinear response in DF with   Availability of data
            stress concentration around the ankle region. Increasing
            AFO thickness enhanced stiffness during both loading   The data that support the findings of this study are available
            conditions with minimal impact on stress distribution,   from the corresponding author upon reasonable request.
            while the AFO stiffness–thickness relationship can
            be described by a power function. Trimline locations   References
            influenced AFO stiffness, with limited effect from inferior   1.   Graham HK, Rosenbaum P, Paneth N, et al. Cerebral palsy.
            trim depth but linear reductions in stiffness with further   Nat Rev Dis Primers. 2016;2:15082.
            posterior trimming. Larger trim depths reduced stress      doi: 10.1038/nrdp.2015.82
            concentration around the ankle, potentially leading to
            better fatigue resistance.                         2.   Ma N, Gould D, Camathias C, Graham K, Rutz E. Single-
                                                                  event multi-level surgery in cerebral palsy: a bibliometric
               Currently, AFO design relies heavily on observational   analysis. Medicina. 2023;59(11).
            assessments and clinical experience. 3D printing offers      doi: 10.3390/medicina59111922


            Volume 10 Issue 3 (2024)                       529                                doi: 10.36922/ijb.3390
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