Page 75 - IJB-5-2
P. 75

Zhang Y
           technology. Certain opinions might be a bit harsh, but our   6.   Ziaie  B,  Baldi  A,  Lei  M, et  al., 2004, Hard and Soft
           conclusion that neither field is established well enough to   Micromachining  for  BioMEMS:  Review  of  Techniques
           make an impact would stand. The capability of 3D-printed   and  Examples  of  Applications  in  Microfluidics  and  Drug
           microfluidics  has  not  surpassed  its  conventional   Delivery. Adv Drug Deliv Rev, 56(2):145-72. DOI 10.1016/j.
           counterpart. An alternative fabrication method is unlikely   addr.2003.09.001.
           to make a disruptive advancement to a well-established
           field of microfluidics. Microfluidics-enabled 3D-printing   7.   Shawgo RS, Grayson ACR, Li Y, et al., 2002, BioMEMS for
           brings more possibility to multimaterial and multiphase   Drug Delivery. Curr Opin Solid State Mater Sci, 6(4):329-34.
           printing,  but  it  is  currently  limited  to  extrusion-based   8.   Tay  FE,  2002,  Microfluidics  and  BioMEMS  Applications.
           3D-printing  and  faces  difficulty  in  extending  to  other   Berlin, Germany: Springer.
           3D-printing modalities.                             9.   Bashir  R,  2004,  BioMEMS:  State-of-the-art  in  Detection,
             For  3D-printed  microfluidics  to  make  a  real  impact,   Opportunities  and  Prospects.  Adv Drug Deliv  Rev,
           new  multimaterial,  multiprocess  and  multiscale
           3D-printing technologies must be developed to address   56(11):1565-86. DOI 10.1016/j.addr.2004.03.002.
           the issues such as surface quality, fabrication speed, and   10.  Xia Y, Whitesides GM, 1998, Soft Lithography. Angew Chem
           multifunctionality.  3D-printed  microfluidics  will  only   Int Ed, 37(5):550-75.
           be recognized as a field of its own if a multicomponent   11.  Unger  MA,  Chou  HP, Thorsen T, et  al., 2000, Monolithic
           3D  microfluidic  device  for  high-value  biomedical   Microfabricated  Valves  and  Pumps  by  Multilayer  Soft
           applications  can  be  monolithically  fabricated  within  a   Lithography.  Science,  288(5463):113-6.  DOI  10.1126/
           reasonably short timeframe. This goal might be achieved   science.288.5463.113.
           by  applying  microfluidics-enabled  3D-printing  to
           3D-printed  microfluidics,  which  would  provide  better   12.  Lecault V, White AK, Singhal A, et al., 2012, Microfluidic
           control for multimaterial and multiphase printing. In any   Single Cell Analysis: From Promise to Practice. Curr Opin
           case, there is still a long way to go.                  Chem Biol, 16(3-4):381-90.
                                                               13.  Kim P, Kwon KW, Park MC, et al., 2008, Soft Lithography
           Acknowledgment                                          for Microfluidics: A Review. Biochip J, 2:1-11.

           The author would like to thank the funding support from   14.  Beebe  DJ,  Mensing  GA,  Walker  GM,  2002,  Physics  and
           Nanyang  Technological  University  (Start  Up  Grant),   Applications of Microfluidics in Biology. Ann Rev Biomed
           National  Additive  Manufacturing  Innovation  Cluster   Eng, 4(1):261-86.
           (NAMIC Singapore, 2017135), Ageing Research Institute for   15.  Minteer  SD,  2006,  Microfluidic  Techniques:  Reviews  and
           Society and Education (ARISE Singapore, ARISE/2017/22)
           and  Singapore  Ministry  of  Education  (Tier  1,  RG49/17).   Protocols.  Vol.  321.  New  York:  Springer  Science  and
           This  research  was  conducted  in  collaboration  with  HP   Business Media.
           Inc.  and  supported/partially  supported  by  the  Singapore   16.  Au AK,  Huynh  W,  Horowitz  LF, et  al.,  2016,  3D-printed
           Government through the Industry Alignment Fund -Industry   Microfluidics.  Angew  Chem Int  Ed,  55(12):3862-81.  DOI
           Collaboration Projects Grant.                           10.1002/anie.201504382.

           References                                          17.  Yazdi AA,  Popma A,  Wong  W, et  al.,  2016,  3D  Printing:
                                                                   An  Emerging  Tool  for  Novel  Microfluidics  and  Lab-on-
           1.   Whitesides  GM,  2006,  The  Origins  and  the  Future  of   a-chip  Applications.  Microfluid  Nanofluidics,  20(3):50.
               Microfluidics. Nature, 442(7101):368.               DOI 10.1007/s10404-016-1715-4.
           2.   Mitchell  P,  2001,  Microfluidics-downsizing  Large-scale   18.  Waheed S, Cabot JM, Macdonald NP, et al., 2016, 3D Printed
               Biology. Nat Biotechnol, 19(8):717.                 Microfluidic  Devices:  Enablers  and  Barriers.  Lab Chip,
           3.   Yin  H,  Marshall  D,  2012,  Microfluidics  for  Single  Cell   16(11):1993-2013. DOI 10.1039/c6lc00284f.
               Analysis. Curr Opin Biotechnol, 23(1):110-9.    19.  Ho  CMB,  Ng  SH,  Li  KHH, et  al., 2015, 3D Printed
           4.   Weibel  DB,  Whitesides  GM,  2006,  Applications  of   Microfluidics  for  Biological  Applications.  Lab Chip,
               Microfluidics in Chemical Biology. Curr Opin Chem Biol,   15(18):3627-37. DOI 10.1039/c5lc00685f.
               10(6):584-91.                                   20.  Au AK, Bhattacharjee N, Horowitz LF, et al., 2015, 3D-printed
           5.   Grayson  ACR,  Shawgo  RS,  Johnson  AM, et  al.,  2004,  A   Microfluidic  Automation.  Lab Chip,  15(8):1934-41.
               bioMEMS Review: MEMS Technology for Physiologically   DOI 10.1039/c5lc00126a.
               Integrated  Devices.  Proc IEEE,  92(1):6-21.  DOI  10.1109/  21.  Bhattacharjee  N,  Urrios  A,  Kang  S,  et  al.,  2016,  The
               jproc.2003.820534.                                  Upcoming  3D-printing  Revolution  in  Microfluidics.  Lab

                                       International Journal of Bioprinting (2019)–Volume 5, Issue 2        71
   70   71   72   73   74   75   76   77   78   79   80