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International Journal of Bioprinting 3D bioprinting for nanoparticle evaluation

Figure 3. Layer-by-layer 3D skin model for evaluation of skin penetration efficacy of nanoparticles (NPs) with different charges. (A) Three-dimensional
skin model fabricated through layer-by-layer deposition of collagen and fibroblasts. (B) Amine-modified positively charged polystyrene NPs penetrate
collagen layers more effectively than hydroxyl and sulfate-modified negatively charged polystyrene NPs. Reproduced with permission from Hou et al.
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Copyright © 2017 Society for Laboratory Automation and Screening.

4. Three-dimensional bioprinted incorporating the patient’s own cartilage cells for better
ear models integration and functionality post-implantation. 58,59
Recent studies have successfully integrated microvascular
Three-dimensional bioprinting technology has networks within these bioprinted ear models, enhancing
significantly advanced the development of ear models tissue viability by mimicking natural nutrient and oxygen
for tissue engineering and regenerative medicine. This supply. Additionally, 3D bioprinting has shown potential
technology allows for the precise deposition of cells and in incorporating therapeutic agents into the printed
biomaterials, enabling the creation of complex structures structures, improving treatments for conditions such as
that closely mimic the natural architecture of human cartilage damage and ear deformities. These technological
tissues. The printing of ear constructs, in particular, uses advancements have revolutionized ear model fabrication,
patient-specific imaging data to achieve high accuracy, offering robust and customizable solutions that enhance

Volume 10 Issue 5 (2024) 11 doi: 10.36922/ijb.4273