Page 429 - IJB-10-5

International Journal of Bioprinting Stability of 3D-printed PEO tablets

Figure 11. Comparison of dissolution behavior of the four formulations (F –F ) prepared by the (a) hot-melt extrudate (HME) and (b) 3D-printing
4
1
method.

Table 8. Kinetic parameters for F –F prepared as a physical mixture (PM), hot-melt extrudates (HME), and by 3D printing.
1 4
Kinetic Parameter F 1 F 2 F 3 F 4
model PM HME Printed PM HME Printed PM HME Printed PM HME Printed
Zero-order R 2 0.991 0.97 0.951 0.992 * 0.958 0.97 0.991 0.967 0.965 0.992 * 0.957 0.957
First-order R 2 0.996 * 0.859 0.939 0.901 0.875 0.877 0.997 * 0.990 0.986 0.989 0.998 * 0.981
Higuchi R 2 0.985 0.992 * 0.994 * 0.976 0.990 * 0.996 * 0.988 0.997 * 0.999 * 0.988 0.998 * 1.00
Korsmeyer- R 2 0.979 0.98 0.976 0.976 0.990 * 0.969 0.959 0.845 0.877 0.939 0.935 0.869
Peppas n 0.77 1.29 1.16 1.05 1.17 1.03 0.85 1.28 0.94 1.02 1.04 0.90
2
Note: denotes Highest value of R . Abbreviations: PM: Physical mixture; HME: Hot-melt extrudate.
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Volume 10 Issue 5 (2024) 421 doi: 10.36922/ijb.4055