Page 427 - IJB-10-5

International Journal of Bioprinting Stability of 3D-printed PEO tablets

Figure 9. Dissolution curves of F (a) and F (b), presented with error bars and the dissolution efficiency (DE%) values for physical mixture (PM), hot-melt
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extrudate (HME), and 3D-printed tablets.
Figure 10 displays the dissolution profiles of the four rate than F and F (containing EC) in both HME and
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formulations (F –F ) made into PM tablets. The smaller 3D-printed tablets. Moreover, F and F had similar release
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standard deviation bars observed indicate that the profiles, i.e., f = 88.08 and 65.28 for HME and 3D-printed
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dissolution behavior is more consistent in F and F tablets tablets, respectively, despite having different M of PEO.
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containing EC (as opposed to HPC in F and F ). An overall Similarly, F and F had similar release behavior, i.e., f =
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faster release for F and F containing 0.9 M PEO infers the 83 and 86.45 for HME and 3D printed tablets, respectively.
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impact of the M of PEO; formulations containing the 7 This pattern was also observed in other studies, where the
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M PEO (F and F ) have a stronger gelling behavior and dissolution profiles of different M PEOs were relatively
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slower release. The strong gelling behavior of PEO 7 M similar after thermal processing. Based on such findings
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appears to dominate the effects of HPC in F and EC in and considering GPC-proven PEO degradation in heat-
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F , as both formulations have similar dissolution profiles processed methods, it can be suggested that after a specific
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(f = 84.86). However, the effect of HPC (hydrophilic) or degradation in the M of PEO, gelling behavior becomes
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EC (hydrophobic) on drug release was more noticeable weak, and drug release becomes less sensitive to PEO M .
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in F and F , and the release from F (PEO/HPC) was A similar pattern was also noticed in a stability study of
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significantly faster than that from F (PEO/EC) (f = 47.53). PEO tablets, where, after eight weeks of storage at high
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When the formulations were thermally processed in release profiles. 8,9 w
HME and 3D printing, the pattern was reversed, and the
dissolution profile followed the hydrophilic or hydrophobic 3.8. Release kinetics
nature of HPC or EC rather than the M of PEO (Figure 11). Dissolution kinetics were also analyzed using four kinetic
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F and F (containing HPC) had a much faster release models (zero-order, first-order, Higuchi, and Korsmeyer-
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Volume 10 Issue 5 (2024) 419 doi: 10.36922/ijb.4055