Page 423 - IJB-10-5

International Journal of Bioprinting Stability of 3D-printed PEO tablets

Figure 6. Flak-shaped powders after grinding filaments in the ball mill.

brittle fracture under conventional grinding methods, 33,34 size of EC-containing formulations can be attributed to the
such as ball-milling used in this study. Usually, cryogenic presence of DBS plasticizer in EC fractions. The addition
or wet grinding is employed to produce fine particles of of plasticizers can increase material ductility and reduce
plastic polymers. 33,34 its brittleness, increasing the average particle size of the

Regardless of the M of PEO, it is obvious that ground material. 35
w
grinding the filaments containing EC (F and F ) produces Regarding the M of PEO, formulations with PEO
3
w
4
considerably larger particles compared to those containing of a higher M (e.g., 7 M) produced finer particle sizes
w
HPC (F and F ). The arithmetic average sizes of F and upon grinding the filaments. Ground filaments of F
2
1
1
3
F ground filaments were 1352.69 and 1796.91 µm, containing HPC/PEO 7 M had a smaller average size
4
respectively, while those for F and F were much smaller than that of F containing HPC/PEO 0.9 M (530.56 vs.
2
2
1
at 530.56 and 919.47 µm, respectively. The large particle 919.47 µm, respectively). Similarly, the average size of F
3

Figure 7. Size distribution based on the retained fraction (%) in each sieve for ground filaments of all formulations, presented as the mean ± SD for each
formula. Abbreviation: pan: powder size <63 µm.

Volume 10 Issue 5 (2024) 415 doi: 10.36922/ijb.4055