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ORIGINAL ARTICLE

           Effects of Topology Optimization in Multimaterial 3D

           Bioprinting of Soft Actuators



           Ali Zolfagharian *, Martin Denk , Abbas Z. Kouzani , Mahdi Bodaghi ,
                            1
                                            2
                                                                                  3
                                                                 1
           Saeid Nahavandi , Akif Kaynak   4
                            4
           1 School of Engineering, Deakin University, Geelong 3216, Australia
           2 Institute for Material and Building Research, Munich University of Applied Sciences, Munich, 80335, Germany
           3 Department of Engineering, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS,
           United Kingdom
           4 Institute for Intelligent Systems Research and Innovation (IISRI), Deakin University, Geelong, 3216, Australia

           Abstract: Recently, there has been a proliferation of soft robots and actuators that exhibit improved capabilities and adaptability
           through three-dimensional (3D) bioprinting. Flexibility and shape recovery attributes of stimuli-responsive polymers as the
           main components in the production of these dynamic structures enable soft manipulations in fragile environments, with
           potential  applications  in  biomedical  and  food  sectors.  Topology  optimization  (TO),  when  used  in  conjunction  with  3D
           bioprinting with optimal design features, offers new capabilities for efficient performance in compliant mechanisms. In this
           paper, multimaterial TO analysis is used to improve and control the bending performance of a bioprinted soft actuator with
           electrolytic stimulation. The multimaterial actuator performance is evaluated by the amplitude and rate of bending motion
           and compared with the single material printed actuator. The results demonstrated the efficacy of multimaterial 3D bioprinting
           optimization for the rate of actuation and bending.

           Keywords: Multimaterial, Three-dimensional bioprinting, Topology optimization, Soft actuator, Soft robot

           *Corresponding Author: Ali Zolfagharian, School of Engineering, Deakin University, Geelong, 3216, Australia; a.zolfagharian@deakin.edu.au
           Received: February 17, 2020; Accepted: March 17, 2020; Published Online: April 10, 2020
           Citation:  Zolfagharian  A,  Denk  M,  Kouzani  AZ,  et al.,  2020,  Effects  of  Topology  Optimization  in  Multimaterial  3D
           Bioprinting of Soft Actuators, Int J Bioprint, 6(2):260. DOI: org/10.18063/ijb.v6i2.260.

           1 Introduction                                      in  the  additive  manufacturing  and  research
                                                               in  responsive  materials [3,4] .  Printing  in  layers
           Manufacturing  in  robotics  has  become  easier    permits  variation  of  mechanical  properties
           with the introduction of three-dimensional (3D)     across the cross section by appropriate variation
           printing, enabling processing of key components     of  layering  materials  with  different  mechanical
           in  a  single  step,  thus  circumventing  separate   and  thermal  properties .  Furthermore,  instead
                                                                                      [5]
           manufacturing  and  assembly  processes .  The      of  solid  infill,  the  3D  printing  process  allows
                                                   [1]
           emergence  of  soft  robotics  accompanied  by      printing  of  porous  layers  which  may  improve
           the  advancements  in  additive  manufacturing      flexibility and bending amplitude of the resulting
           enabled  design  and  production  of  creative      composites . The adoption of machine learning-
                                                                          [6]
           soft  robots  that  are  capable  of  handling  fragile   based  design  in  3D  printing  of  composite
           objects and accomplishing delicate work . The       structures  involves  practical  trials  until  the
                                                    [2]
           recent  proliferation  of  four-dimensional-printed   desired  output  is  achieved [7-10] .  However,  the
           soft  robots  stems  from  both  developments       non-linear and temperature sensitive behavior of

           © 2020 Zolfagharian, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International
           License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the
           original work is properly cited.
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