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Zolfagharian, et al.
           polymeric soft actuators make the design more       structural optimization (BESO) , and level set
                                                                                             [19]
                                                                                                            [20]
           challenging .  Finite  element  analysis  (FEA)     can be used to design a structure with maximum
                      [9]
           could  be  used  as  a  digital  tool  in  conjunction   stiffness  density.  The  structural  optimization
           with  topology  optimization  (TO)  to  simulate    method  permits  the  normalized  density  of  1
           the behavior of soft actuators before proceeding    and  ,  where    describes  the  minimum
                                                                                                            [21]
           with the fabrication process . Computer-aided       material value, to not to create singular matrices .
                                       [11]
           design  and  the  performance  attributes  of  the    The  actuation  of  bioprinted  polyelectrolyte
           design  are  assessed  by  optimization  engines  to   hydrogel  used  in  this  paper  is  caused  by  the
           save the labor and time in finalizing the design    Donnan effect where the applied voltage causes
           in  an  additive  manufacturing-oriented  design    an ionic concentration gradient in the direction of
           approach [12] .                                     the applied electric field that initiates an osmotic
             There have been a number of studies on the        pressure  gradient  within  the  hydrogel,  causing
           dynamic  response  of  hydrogels  to  external      the reversible bending of the actuator. In recent
           stimuli  where  hydrogels  were  3D  printed  into   study,  the  relationship  between  the  actuator
           shape memory plastics to produce structures that    deflection,  applied  voltages,  ion  concentration,
           exhibit  reversible  volumetric  strains  of  up  to   and reaction parameters to achieve the maximum
           10  times  the  original  volumes,  thus  simulating   deflection  were  determined.  Moreover,  it  was
           muscle    behavior [13-15] .   Reversible   bending   demonstrated  that  the  actuator  deflection  was
           motion  of  a  hydrogel  was  demonstrated  in  an   pattern  dependent  and  the  lattice  patterned
           electrochemical cell where the electrochemically    specimen  exhibited  larger  bending  deflection
           induced actuation was achieved by the osmotic       compared  to  that  of  cast  solid  actuator [22] .
           pressure  caused  by  the  Donnan  effect [16] .  In   Although  the  latticed  sample  enabled  better
           another  study,  electroactive  polymers  were      bending performance, the pattern can be further
           used  to  manifest  reversible  movement  due  to   optimized  to  maximize  bending  using  equal
           the diffusion of dopant anions through a porous     quantity of the material.
           membrane  within  the  layered  structure  of  the    In this study, we designed a soft actuator with
           composite polymer  [17] .                           an  optimized  lattice  pattern  using  two  different
             This  paper  investigates  the  optimization      materials.  In  this  regard,  boundary  conditions
           of  the  multimaterial  printing  of  electrically   were  defined  based  on  a  cantilever  beam  with
           responsive  3D  bioprinted  soft  actuator  with    a  distributed  force  caused  by  osmotic  pressure
           respect to actuation performance. FEA and TO        created  in  the  electrolyte.  The  objective  of  this
           were  used  to  investigate  the  effect  of  material   study  is  to  optimize  the  actuator  performance
           configuration on bending amplitude of the soft      through material configurations in different layers
           actuator at constant volume fraction. This study    while  maintaining  the  volume  fraction  of  the
           demonstrates  an  approach  to  optimized  design   material.
           that can be applied to other similar soft robot and   The  loading  and  boundary  conditions  are
           actuator systems.                                   illustrated in Figure 1. A stress-based TO would
                                                               require  several  constraints  that  increase  the
           2 Two-material TO of soft actuator                  complexity  of  computation;  moreover,  the  non-
                                                               linearity of the stresses would cause computational
           TO  aims  at  optimizing  design  by  arranging     overload  due  to  convergence  difficulties .  The
                                                                                                       [23]
           material  placement.  For  example,  materials  can   TO modeling for the soft actuator was based on
           be removed from low stress areas and applied to     the  SIMP  approach  and  the  design  goal  set  to
           the locations of high stress resulting in a porous   minimum  strain  energy  or  maximum  stiffness
           structure  with  variable  density.  Common  TO     with optimal structural configuration. To control
           methods,  namely,  solid  isotropic  material  with   the  actuator  stiffness  and  the  optimization
           penalization (SIMP) , bidirectional evolutionary    convergence, a volume constraint was set .
                              [18]
                                                                                                      [24]
                                       International Journal of Bioprinting (2020)–Volume 6, Issue 2        51
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