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Effects of topology optimization in multimaterial 3D bioprinting of soft actuators
                        A






















                        B
















           Figure 1. Computer-aided design models of the actuators (A) two-material three-dimensional printing,
           (B) mechanical forces and boundary constraints.

           2.1 Sensitivity analysis                            Ω, which is transferred into N discrete elemental
                                                               counterparts. Defining continuous design variables
           Direct  objectives,  such  as  stresses  and  strains,   0 <ρ  <1, the design domain, Ω. By applying a power
           could be used to determine sensitivities. The strain   law, interpolation and information of the material
                                                                   e
           compliance change with respect to the improved      properties,  E   and  E   a  single  element  Young’s
                                                                           1
                                                                                   2,
           variant,     =  1 uKu,  is  opted  as  the  most   modulus, E , could be described as follows :
                               T
                                                                                                       [28]
                     Strain
                            2                                     E     e  E +( E − )     p ,e  =12, , …, N   (2)
                                                                                     E  ( ) =
           common  approach  [25,26] .  A  combination  of  both   e   e     2    1    2  e
           solid and distributed material models is used for     Furthermore, the elemental stiffness matrix, K
           the determination of the sensitivities . The strain   for two materials then could be derived as follows: e
                                             [27]
           energy  of  the  element  can  be  used  when  the     K =  K (  E +( E − ) ),  p  e     …, N  (3)
                                                                                      E
           element size does not have a significant effect on      e     0, e  2   1    2  e    =12, ,
           the magnitude of the local strain energy. The strain   Where, K is a single elemental stiffness matrix
           energy density,  , is calculated as an appropriate   for a unit solid material. The strain energy density
                                                                          0,e
                           obj
           objective function for each element, e, to optimize   of each element with the volume V and the node
           uneven structured meshes as follows:                displacement u  could be obtained as follows:
                                                                                                 e
                                                                                        T
                          ∂       1 ∂u Ku                                   e       1 uK u
                                       T
                       =    Strain  =                  (1)                       =    e  ee               (4)
                           ∂  obj ,e    2 ∂                                  obj e,  2  V e
             Where, K and u are the stiffness matrix and the     By  differentiating  the  element-wise  strain
           node  displacement  vectors  over  the  field  design,   energy  with  respect  to  the  normalized  element
           52                          International Journal of Bioprinting (2020)–Volume 6, Issue 2
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