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International

                                                                         Journal of Bioprinting



                                        REVIEW ARTICLE
                                        3D-printed electronics for biomedical

                                        applications



                                        Minsu Ryoo 1 id , Daeho Kim , Junseop Noh , and Song Ih Ahn *
                                                               1
                                                                           1
                                                                                           2 id
                                        1 School of Mechanical Engineering, Pusan National University, Pusan, Republic of Korea
                                        2 Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology
                                        (KAIST), Daejeon, Republic of Korea



                                        Abstract
                                        Biomedical electronics have garnered significant interest due to the rising demand
                                        for advanced healthcare devices for diagnosis, monitoring, and treatment. Three-
                                        dimensional (3D) printing, or additive manufacturing, has emerged as an attractive
                                        fabrication method for developing these advanced biomedical devices. Its unique
                                        features, such as versatility, cost-effectiveness, and rapid prototyping capabilities,
                                        when combined with medical imaging technologies enable the creation of highly
                                        precise and customized patient-specific structures. Extensive research in the field
                                        of 3D printing has focused on developing biomedical devices, including wearable
                                        and implantable devices, as well as scaffolds or platforms. Recently, the integration
                                        of 3D printing with state-of-the-art electronic materials, known for their high
                                        flexibility, conductivity, stretchability, stability, and biocompatibility, has led to
                                        the  development  of  innovative  biomedical  electronics.  In  this  review,  we  outline
                                        the recent advancements in 3D printing technologies and their applications in
                                        bioelectronic devices. Firstly, we describe various 3D printing methods and printable
            *Corresponding author:      electronic materials, highlighting their advantages and limitations. Subsequently,
            Song Ih Ahn (siahn@kaist.ac.kr)  we explore the applications of these technologies in biomedical research, spanning
                                        from surgical guidance and prosthetics to health monitoring devices and tissue-
            Citation: Ryoo M, Kim D, Noh J,



            Ahn SI. 3D-printed electronics for   engineered scaffolds. Finally, this review discusses the current challenges and future

            biomedical applications.    directions to fully exploit the potential of 3D-printed bioelectronic devices, aimed at
            Int J Bioprint. 22024;10(6):4139.    transforming personalized healthcare.
            doi: 10.36922/ijb.4139
            Received: July 3, 2024
            Revised: August 2, 2024     Keywords: Bioelectronics; Biomedical electronics; 3D printing; Biomedical devices;
            Accepted: August 2, 2024    Personalized healthcare
            Published Online: August 7, 2024
            Copyright: © 2024 Author(s).
            This is an Open Access article
            distributed under the terms of the
            Creative Commons Attribution   1. Introduction
            License, permitting distribution,
            and reproduction in any medium,   Three-dimensional (3D) printing has emerged as an innovative technology in
            provided the original work is   biomedical engineering, profoundly impacting personalized medicine and medical
            properly cited.             device fabrication. The ability of 3D printing to fabricate complex patient-specific
            Publisher’s Note: AccScience   structures with high precision and customization has attracted significant attention from
            Publishing remains neutral with   researchers. Moreover, the inherent versatility of material options, design flexibility, cost-
            regard to jurisdictional claims in
            published maps and institutional   effectiveness, and rapid fabrication have led to widespread applications in biomedical
            affiliations.               devices. By layering materials in a controlled manner, 3D printing enables the creation of




            Volume 10 Issue 6 (2024)                        95                                doi: 10.36922/ijb.4139
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