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International Journal of Bioprinting                                      3D-printed bioelectronic devices




            Table 1. Key features of different 3D printing methods for bioelectronic fabrication.
             3D printing method  Techniques  Operation principle  Advantages        Disadvantages
             Material jetting  Thermal   Pressure pulse   High fabrication   Relatively simple  Limited choice of   Generated heat
                            inkjet    generated by air   speed                      materials     could cause
                            printing  bubbles created from   High printing          Support structure   damage to
                                      thermal energy  resolution                    required      materials
                            Piezoelectric  Mechanical pulse   Low cost  Controllable droplet   depending on   Relatively
                            inkjet    generated by a               size             printing structure  expensive
                            printing  piezoelectric actuator                                      compared to
                                                                                                  thermal inkjet-
                                                                                                  based printing
                            Aerosol jet   Precise deposition   High resolution      High initial and maintenance costs
                            printing  of aerosolized ink   Versatile material usage  Low printing speed
                                      containing fine   Capable of creating complex structures  Requirement of specific substrates
                                      particles onto a
                                      substrate
             VAT            SLA       Photocuring     Support-free   Smooth printed   Limited choice   Relatively low
             photopolymerization      resin through a   system     surface          of materials   printing speed
                                      concentrated laser   High printing            (photoresins)  compared to
                                      beam            resolution                    Large amount of   DLP
                            DLP       Photocuring resin by   High level of   High printing speed   waste  Smaller object
                                      projecting an image   accuracy  Simple replacement of   Limited printing   size compared
                                      of a printing layer          light source compared   size   to SLA
                                      onto the resin               to SLA
             Extrusion-based   FDM    Depositing melted   Low cost                  Relatively low resolution
             printing                 thermoplastic   Large object size             Limited choice of materials
                                      materials in filament   Accessibility         Post-processing requirements
                                      form            Less waste                    Low printing speed
                                                      Printable on various substrates
                            DIW       Depositing inks   High fabrication speed      Support structure required depending
                                      using extruders   Simple to perform multi-material printing  on printing structure
                                      (pneumatic, syringe,   Highly customizable    Relatively low resolution
                                      and progressive   Material flexibility
                                      cavity)         Printable on various substrates
            Abbreviations: DIW, direct ink writing; DLP, digital light processing; FDM, fused deposition method; SLA, stereolithography.


            PEDOT:PSS,   graphene,   gold nanoparticles,  and     SLA is one of the earliest and most widely used additive
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            MnO ,  have been used for inkjet printing of electronics.   manufacturing (AM) techniques.  This technique uses a
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            The surface tension should also be within a suitable range   concentrated laser beam on the surface of a photocurable
            (30–70 mN/m) to eject ink without forming satellite   resin to create a pattern in each layer. After one layer of
            droplets in the nozzle. 47                         resin is cured, the platform moves downward to fabricate
                                                               another layer of resin, and this layer-by-layer photocuring
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            2.2. Vat photopolymerization-based 3D printing     step is repeated to construct a 3D object.  A recent study
            Vat photopolymerization-based 3D printing produces   demonstrated its application in the fabrication of multi-
            objects  by  selectively curing  a photocurable  resin  in a   material actuators using a combination of hard and flexible
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            vat  using  a light source.  Vat  photopolymerization-based   material resin formulations.  DLP uses a digital light
            3D printing has gained considerable attention due to its   projector to project the image of a printing layer onto a
                                                               liquid resin.  As the entire layer of liquid resin can be
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            high precision, high printing speed, and smooth printed   cured simultaneously, the printing speed is relatively fast
            surfaces. The photopolymerization process can generally   compared to other methods.  One major challenge of
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            be classified according to the light source used for curing:   vat photopolymerization-based 3D printing is its limited
            stereolithography appearance (SLA), which uses lasers,   choice of materials. To overcome this challenge while
            and digital light processing (DLP), which operates with a   preserving its advantages of printing speed and resolution,
            projector (Figure 1B). 48                          DLP has been integrated with other printing methods to

            Volume 10 Issue 6 (2024)                        97                                doi: 10.36922/ijb.4139
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