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Heart-on-a-chip
To sum up, the development of heart-on-a-chip is Scaffolds for Building Cardiac Tissue. J Thorac Dis,
still in its early stage, and there are barriers to overcome 10:S2312–28.
in its commercialization and clinical applications. https://doi.org/10.21037/jtd.2017.12.92
However, it is believed that heart-on-a-chip is a promising 9. Zhao Y, Rafatian N, Wang E, et al., 2020, Towards Chamber
technique and has a great potential in various biomedical
applications. Specific Heart-on-a-chip for Drug Testing Applications. Adv
Drug Deliv Rev, 165–166:60–76.
Acknowledgments https://doi.org/10.1016/j.addr.2019.12.002

The work was financially supported by National 10. Guerzoni L, Tsukamoto Y, Gehlen DB, et al., 2019, A
Natural Science Foundation of China (51911530694, Layer-by-Layer Single-Cell Coating Technique To Produce
11902245), the Key Research and Development Program Injectable Beating Mini Heart Tissues via Microfluidics.
of Shaanxi (2021GY-294), the Zhejiang Provincial Biomacromolecules, 20:3746–54.
Natural Science Foundation of China (LQ21E050009), https://doi.org/10.1021/acs.biomac.9b00786
and Beilin District Applied Technology Research and
Development Projects in 2020 (GX2027). 11. Derda R, Laromaine A, Mannoto A, et al., 2009, Paper-
supported 3D Cell Culture for Tissue-based Bioassays. Proc
Conflict of interest Natl Acad Sci U S A, 106:18457–62.
The authors declare that they have no conflict of 12. Lind JU, Busbee TA, Valentine AD, et al., 2017, Instrumented
interest. Cardiac Microphysiological Devices via Multimaterial
Three-dimensional Printing. Nat Mater, 16:303.
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