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3D Printer for Anatomic Models
           Table 2. A survey of features considering various additive manufacturing technologies
           Technology       Principle             Soft      Multi‑   Material        Support structures Closed
                                                  materials  material deposition                       cavities
           SLS             Powder bed fusion     Limited    No       Spreading       Powder or printed  No
           BJ              Material jetting      Limited    No       Spreading and   Powder or printed  No
                                                                     droplets
           IJP             Material jetting      Yes        Yes      Droplets        Printed           Limited
           SLA             Vat photo-polymerization Limited  No      Spreading       Liquid or printed  No
           DLP             Vat photo-polymerization Limited  No      Spreading       Liquid or printed  No
           FFF             Extrusion             Limited    Yes      Heated extrusion  Printed         Yes
           DIW             Extrusion             Yes        Yes      Extrusion or    Liquid or printed  Yes
                                                                     droplets
           *Ideal for      Extrusion             Yes        Yes      Extrusion       Printed           Yes
           anatomic models
           *An imaginary technology which we found ideal for anatomic models if mechanical realism is desirable.

               Concerning  the printing  material,  some silicone   component selection. An FFF printer which does not only
           rubbers exhibit  ideal  mechanical  properties  to mimic   apply Delta  or XY-Core kinematics,  but also employs
           various  soft  tissues.  This  also  makes  them  a  popular   a control board that is open-source and easily extended
           casting  material  for  certain  anatomic  models,  where   with the chosen Viscotec extruder was considered highly
           a  casting  mold  of  the  desired  anatomy  is  first  printed   desirable.
           with FFF or SLA, and then filled with a two-component   Finally, a Railcore II 300 ZL open-source FFF 3D
                                                                           [53]
           addition-cured  silicone  rubber [7,9] . However, in multi-  printer system   was  chosen  and  modified  (Figure  1).
           material  printing, the adhesion of the various printing   On this printer, the original  E3D  V6 FFF printhead
           materials is important, unlike in casting. Certain single-  was  extended with the  Viscotec  Vipro-HEAD  3/3
                                                                       [52]
           component  condensation-cured silicone  rubbers may   (Figure 2) . Silicones and other high-viscosity materials
           exhibit an adhesive behavior to some thermoplastic   can be fed into this screw extruder with pressurized air up
           polymer  materials,  which makes these a promising   to 6 bars, from 55 mL cartridges, which are also mounted
           combination  in a multi-material  printing scenario.   on the printhead. If necessary, these can be moved to the
           Therefore, the printer should employ an FFF printhead   frame, which removes their volume and mass limitations,
           for printing thermoplastics, and a continuous extrusion-  enabling a large material supply to the printhead given
           based DIW printhead to print single-component silicone   that the feed pressure is sufficient. The silicone printing
           rubbers.                                            nozzle is connected to the outlet of the extruder through
                                                               a Luer-thread and is secured against unscrewing with a
           2.2. Printer system                                 retainer  part.  These white Luer-adapters and retainers
                                                               were custom-made  for the extruder (Figure  2A).
           For an extrusion-based DIW printhead, various extrusion   A nozzle with 0.33 mm outlet diameter was selected for
           mechanisms, such as syringes, peristaltic pumps and screw   silicone extrusion. The original E3D V6 FFF printhead
           extruders, are available.  However, for high-viscosity   on the other side of the carriage (Figure 2B) is capable of
           and high-precision applications,  screw extruders were   melting and depositing thermoplastic filaments through a
           preferred. The final choice fell on a Vipro-HEAD 3/3 two-  0.4 mm diameter nozzle.
           component printhead by Viscotec GmbH (Töging am Inn,    The printer is controlled by the Duet 2 Wi-Fi control
           Germany) , which enables processing either one or two   electronics,  extended with a Duex 5 extension board,
                   [52]
           single-component silicones, or a two-component silicone.   operating  with  RepRap  v1.18  firmware . The  system
                                                                                                 [54]
           In this study, only one single-component silicone rubber   can be connected to a personal computer (PC) through
           was used.                                           a Wi-Fi network, and print jobs can be started through
               Regarding printer mechanics from the standpoint   the Duet Web Interface, which is accessible through an
           of  printing  soft  and  flexible  materials,  it  is  important   internet browser running on the PC. The general printer
           that the building platform only moves in the axis of the   configuration,  including  the  printhead  definitions  and
           building direction (usually labeled “Z”), so that it does   dosing calibration settings are done by modifying a file
           not shake the printed objects horizontally during printing.   stored on the Duet 2 Wi-Fi board. The slicing software
           The printer kinematics which fulfills this criterion are the   used to  generate  G-codes for printing  objects  is Prusa
           so-called XY-Core and the Delta kinematics. Hardware   Slicer (version  2.1), an open-source slicer originally
           and software formed another  important  aspect  in the   made for filament-based printers . The user can easily
                                                                                          [55]
           148                         International Journal of Bioprinting (2021)–Volume 7, Issue 4
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