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RESEARCH ARTICLE

           Convex and Concave Model 3D Printing for Designing

           Right-side Bronchial Blocker for Infants


           Xiaomin Duan , Wei Wang , Wenping Ma , Zhenhui Mao , Fangliang Xing , Xin Zhao *
                                       1†
                                                      2†
                                                                                                   3
                          1†
                                                                                        4
                                                                      3
           1 Department Radiology-Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health,
           Beijing 100045, China
           2 Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070,
           China
           3 Department Anesthesiology-Beijing Children’s Hospital, Capital Medical University, National Center for Children’s
           Health, Beijing 100045, China
           4 Beijing Intelligent Entropy Science and Technology Co Ltd., Beijing 100176, China
           † These authors contributed equally to this work.

           Abstract: It is technically challenging for pediatric anesthesiologists to use bronchial blocker (BB) to isolate the lungs of
           infants during thoracoscopic surgery. Further, BB currently sold in the market cannot match the anatomical characteristics of
           the infants, especially on the right main bronchus. It may easily cause poor exhaustion of the right upper lobe, which leads
           to interference with the thoracoscopic surgical field. The two dimensional reconstruction data of 124 normal infants’ airways
           were extracted from the medical image database of Beijing Children’s Hospital for statistical analysis. After using linear
           fitting and goodness-of-fit test, a good linear relationship was detected between infant age and various parameters related to
           aid in designing a new BB for infants (R =0.502). According to the growth and development rate of infants, the DICOM files
                                           2
           of airway CT scan of 7 infants aged 30, 60, 90, 120, 180, 270, and 360 days were selected to print non-transparent convex
           and transparent concave 3D models. The non-transparent convex model was precisely measured to obtain the important
           parameters for BB design infants only, to complete the design of BB, to generate the sample, and to verify the blocking effect
           of produced sample in transparent concave three-dimensional (3D) model.
           Keywords: Three-dimensional printing; Infant; Bronchial blocker; Airway management

           *Correspondence to: Xin Zhao, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045,
           China; zhaoxin@pumch.cams.cn
           Received: March 04, 2021; Accepted: March 29, 2022; Published Online: April 29, 2022

           Citation: Duan X, Wang W, Ma W, et al., 2022, Convex and concave model 3D printing for designing right-side bronchial blocker for infants,
           Int J Bioprint. http://doi.org/10.18063/ijb.v8i3.555

           1. Introduction                                     new-style  bronchial  blocker  (BB) [5,6] . Nevertheless,  the
                                                               BB currently sold in the market cannot nicely match the
           When animal  experiments  fail to satisfy design    anatomical characteristics of the infants. The BB is an
           requirements  or  the  clinical  trials  are  hard  to  conduct,   important medical consumable for airway management
           3D printing can aid in designing medical  devices   during thoracoscopic surgery and general anesthesia in
           and consumables [1-4] . For example,  during an infant’s   infant patients. BB can block the bronchi of the surgical
           thoracoscopic surgery, it is required to block the bronchus   side and prevent the contamination of the healthy lung
           and collapse the lung of surgery side to generate a full   tissues by blood secretions or tumor cells from the
           operation field for the operator. However, it is problematic   surgical side of the lung. In addition, it may help to drain
           for animal models to express these delicate operations.   residual air from the surgical side of the lung.
           Our  3D printing model will fully display bronchi in    There  are  three  key  points  to  consider  when
           practice to provide reference and guidance for designing   designing BB. First, the transverse diameter (TD) of the

           © 2022 Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution and
           reproduction in any medium, provided the original work is cited.
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