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Wang, et al.
           Table  2.  Bone biomechanical  studies focusing on the evaluation  of mechanical  advantage,  dynamic  stability, and post-operative
           implants-relative complications.
           Indications     Number      Osteotomy methods   Module   Principle        Clinical measure    Ref.
                           of
                           subjects
           PMRI elbow      7          Manual osteotomy    None      O’Driscoll type   Contact pressure   [25]
                           cadaveric   along the outline on         2-2             and area values
                           arms       the trochlear surface                         throughout 0° to 90°
                                                                                    flexion arc
           Coronoid-       8          Manual osteotomy    None      Regan-Morrey    Evaluation of the    [26]
           deficient elbow  cadaveric   parallel to flat spot       type 2          efficacy of coronoid
                           arms       of ulna using micro                           prosthesis in elbow
                                      sagittal saw                                  stabilization
           Intra-articular   16       Manual osteotomy    None      41-C2           Biomechanical        [24]
           tibial plateau   cadaveric   in meta-diaphyseal          AO-classification  comparison of
           fractures       tibiae     intersection and                              intramedullar versus
                                      medial epicondyle                             extramedullar
                                                                                    stabilization
           Intertrochanteric   16     Manual osteotomy    None      Evans-Jensen    Biomechanical        [11]
           fractures       cadaveric   based on                     classification  comparison of
                           femurs     classification                                InterTAN and PFNA
           Femoral neck    30         Manual osteotomy    None      Pauwel type B   Biomechanical        [4,10]
           fractures       cadaveric   with thin bladed                             analysis of fixation
                           femurs     straight sagittal saw                         devices
           Odontoid        7 cadavers  Manual osteotomy at   None   Type II odontoid   Evaluation of the   [27]
           fracture                   the base of odontoid          fracture        application of
                                                                                    cervical collar in the
                                                                                    reduction of cervical
                                                                                    spine motion
           Intertrochanteric   24     Manual osteotomy    None      31-A3.3         Biomechanical         [5]
           femur fracture  composite   with oscillating saw         AO-classification  comparison of
                           Sawbones                                                 different fixation
                                                                                    techniques
           Femoral   neck  20         Manual osteotomy    Saw-      31-B2           Biomechanical         [9]
           fractures       cadaveric   according to a     guide     AO-classification  comparison of
                           femora     custom-made                                   different fixation
                                      saw-guide                                     implants
           Periprosthetic  26         Manual osteotomy    Cutting   N/A             Analysis of           [8]
           Femoral Fracture  composite   according to a cutting   guide             periprosthetic
                           Sawbones   guide                                         femoral fracture risk
                                                                                    in different implants
           PMRI, posteromedial rotatory instability; InterTAN, proximal femoral nail; PFNA, proximal femoral nail anti-rotation; N/A: not applicable

           direction to accommodate different bone morphology.   et al. [12]  in the biomechanical performance comparison
           Based on this, the blade of an oscillating saw was   of  internal  fixation  of  femoral  neck  fractures  with
           guided in circular slots around the bone. Unfortunately,   posterior comminution.
           the study did not evaluate the accuracy of osteotomy.   Tang  et al.  proposed  “triangular  stability  theory”
           The broad access of traditional industrial designs is   of proximal femur and pointed out that the stabilization
           limited by several disadvantages such as time-  and   of proximal femur relies on structural mechanical model
           manpower-consuming  aspects,  high  consumption,    formed by the medial,  lateral, and upper sides [13,28] .
           complexity, high manufacturing cost, and difficulties of   The medial side forms the oblique support of proximal
           refinement  and  personalization  of  the  products.  CAD   femoral cantilever structure, greatly reducing the bending
           and 3D printing can help improve this outlook.  The   stress  and  deflection  of  bone  structure. The  upper  side
           same osteotomy-aided module was used by Rupprecht   connects the medial and lateral edges of proximal femur

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