Page 207 - IJB-9-1

International Journal of Bioprinting

RESEARCH ARTICLE
FeS -incorporated 3D PCL scaffold improves new
2
bone formation and neovascularization in a rat
calvarial defect model

Donggu Kang , Yoon Bum Lee , Gi Hoon Yang , Eunjeong Choi , Yoonju Nam ,
1
1†
2†
1
1
Jeong-Seok Lee , KyoungHo Lee , Kil Soo Kim , MyungGu Yeo , Gil-Sang Yoon ,
1
5
4
2
2,3
SangHyun An *, Hojun Jeon *
2
1
1 Research Institute of Additive Manufacturing and Regenerative Medicine, Baobab Healthcare Inc.,
Ansan, Gyeonggi-Do, 15588, South Korea
2 Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub),
Dong-gu, Daegu 41061, South Korea
3
College of Veterinary Medicine, Kyungpook National University, Daegu 41566, South Korea
4 Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI
Hub), Dong-gu, Daegu 41061, South Korea
5 Molds & Dies Technology R&D Group, Korea Institute of Industrial Technology (KITECH), Bucheon-
si, Gyeonggi-Do, 14441, South Korea
(This article belongs to the Special Issue: Advances in 3D bioprinting for regenerative medicine and drug
screening)
Abstract
† These authors contributed equally
to this work. Three-dimensional (3D) scaffolds composed of various biomaterials, including
metals, ceramics, and synthetic polymers, have been widely used to regenerate bone
*Corresponding authors: defects. However, these materials possess clear downsides, which prevent bone
Sang-Hyun An
(ash4235@kmedihub.re.kr) regeneration. Therefore, composite scaffolds have been developed to compensate
Hojun Jeon these disadvantages and achieve synergetic effects. In this study, a naturally
(hojun@baobabhcare.com)
occurring biomineral, FeS , was incorporated in PCL scaffolds to enhance the
2
Citation: Kang D, Lee YB, Yang mechanical properties, which would in turn influence the biological characteristics.
GH, et al., 2023, FeS -incorporated The composite scaffolds consisting of different weight fractions of FeS were 3D
2
3D PCL scaffold improves new bone 2
formation and neovascularization in printed and compared to pure PCL scaffold. The surface roughness (5.77-fold) and
a rat calvarial defect model. the compressive strength (3.38-fold) of the PCL scaffold was remarkably enhanced
Int J Bioprint, 9(1): 636. in a dose-dependent manner. The in vivo results showed that the group with PCL/
https://doi.org/10.18063/ijb.v9i1.636
FeS scaffold implanted had increased neovascularization and bone formation
2
Received: July 29, 2022 (2.9-fold). These results demonstrated that the FeS incorporated PCL scaffold might
Accepted: September 02, 2022 2
Published Online: November 4, be an effective bioimplant for bone tissue regeneration.
2022
Copyright: © 2022 Author(s). Keywords: FeS ; PCL; 3D printed; Mechanical properties; Bone formation
This is an Open Access article 2
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium, 1. Introduction
provided the original work is
properly cited. Bone is a dynamic tissue with a hierarchical structure composed of organic and inorganic
[1]
Publisher’s Note: Whioce components . This complex tissue is responsible for important body functions,
Publishing remains neutral with including locomotion, framework, as well as support and protection of internal organs .
[2]
regard to jurisdictional claims in
published maps and institutional The hierarchical and complex structure of the bone offers exceptional mechanical
[3]
affiliations. properties, which contributes to load-bearing functions . Bones have the ability to
Volume 9 Issue 1 (2023) 199 https://doi.org/10.18063/ijb.v9i1.636