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International Journal of Bioprinting 3D bioprinting of tissue with carbon nanomaterials
coming years, researchers should employ the underutilized Writing – review & editing: Suck Won Hong, Hojae Bae,
bioprinters to fabricate tissue constructs. Bongju Kim, Yu-Shik Hwang
(iv) Several researchers have utilized encapsulated Conceptualization & revision: Jae Min Cha, Dong-Wook Han
CFNs, while some others have used bare nanomaterials. Ethics approval and consent to participate
As the stabilization of nanoparticles plays a crucial role
in biocompatibility, a comparative study employing Not applicable.
encapsulated and non-encapsulated CFNs-containing
printable gels should be conducted. Consent for publication
(v) Apart from electrochemical properties, CFNs Not applicable.
have been used as fillers to improve the mechanical
strength of printable gels. Researchers should attempt to Availability of data
prepare modified or doped CFNs with reactive groups Not applicable.
on the surface, which can crosslink polymers and express
multifunctionality during application. References
(vi) Enhanced cell proliferation is the major biological
outcome of the combined CFNs with printable gel. Despite 1. Gopinathan J, Noh I, 2018, Recent trends in bioinks for 3D
the studies that have been performed on molecular level, printing. Biomater Res, 22:11.
researchers have never discussed how nanomaterials 2. Cha M, Jin YZ, Park JW, et al., 2021, Three-dimensional
interact among themselves and with the cells in the tissue printed polylactic acid scaffold integrated with BMP-2 laden
construct after fabrication. A detailed analysis of this would hydrogel for precise bone regeneration. Biomater Res, 25:35.
assist nanotechnologists in their venture of exploring more 3. Murphy SV, Atala A, 2014, 3D bioprinting of tissues and
about CFNs-printable gels. organs. Nat Biotechnol, 32:773–785.
We anticipate that researchers with interdisciplinary 4. Guvendiren M, Molde J, Soares RMD, et al., 2016, Designing
backgrounds will advance the field of TE and regenerative biomaterials for 3D printing. ACS Biomater Sci Eng, 2:1679–
medicine using CFNs-containing printable gels by 1693.
considering the aforementioned problems and suggestions. 5. Kang MS, Kwon M, Lee SY, et al., 2022, In situ crosslinkable
collagen-based hydrogels for 3D printing of dermis-mimetic
Acknowledgments constructs. ECS J Solid State Sci Technol, 11:045014.
None. 6. Kang MS, Kwon M, Lee SH, et al., 2022, 3D printing of skin
equivalents with hair follicle structures and epidermal-
Funding papillary-dermal layers using gelatin/hyaluronic acid
hydrogels. Chem Asian J, 17: e202200620.
This research was supported by the Basic Science 7. Ozbolat IT, Peng W, Ozbolat V, 2016, Application areas of
Research Program through the National Research 3D bioprinting. Drug Discov Today, 21:1257–1271.
Foundation of Korea (NRF) funded by the Ministry
of Education (No. 2022R1I1A1A01064416), the NRF 8. Weng T, Zhang W, Xia Y, et al., 2021, 3D bioprinting for skin
grant funded by the Korean Government (MSIT) (Nos. tissue engineering: Current status and perspectives. J Tissue
2021R1A2C2006013 and 2020R1F1A1072695), and the Eng, 12:20417314211028574.
Ministry of Trade, Industry and Energy, Korea, under 9. Gu Z, Fu J, Lin H, et al., 2020, Development of 3D bioprinting:
the “Regional Innovation Cluster Development Program From printing methods to biomedical applications. Asian J
(R&D, P0015342)” supervised by the Korea Institute for Pharm Sci, 15:529–557.
Advancement of Technology (KIAT). 10. Gudapati H, Dey M, Ozbolat I, 2016, A comprehensive
review on droplet-based bioprinting: Past, present and
Conflict of interest future. Biomaterials, 102:20–42.
The authors declare no conflicts of interest. 11. Derby B, 2010, Inkjet printing of functional and structural
materials: Fluid property requirements, feature stability, and
Author contributions resolution. Annu Rev Mater Res, 40:395–414.
12. Nakamura M, Kobayashi A, Takagi F, et al., 2005,
Writing – original draft: Iruthayapandi Selestin Raja, Moon Biocompatible inkjet printing technique for designed
Sung Kang seeding of individual living cells. Tissue Eng, 11:1658–1666.
Volume 9 Issue 1 (2023) 194 https://doi.org/10.18063/ijb.v9i1.635

