Page 82 - IJB-9-2

International Journal of Bioprinting Clinical applications of bioprinted active bone

autologous PRP as another main component of the bioink. Methodology: Yongqiang Hao
PRP is an extract of autologous whole blood containing a Writing – original draft: Bojun Cao
high concentration of platelets and small amounts of white Writing – review and editing: Bojun Cao and Yongqiang Hao
t
blood cells and fibrin. Platelets are a ctivated o release a
variety of growth factors, including platelet-derived growth Ethics approval and consent to participate
factor (PDGF), transforming growth factor (TGF), vascular This study was approved by the Ethics Committee of the
endothelial growth factor (VEGF), and insulin-like growth Ninth People’s Hospital, Shanghai Jiao Tong University
factor (IGF), and play an important role in promoting School of Medicine (SH9H-2021-T245-1). Informed
bone formation and angiogenesis [18,19] . In addition, the consent was obtained from the patient.
preparation of PRP is simple, and only a small amount of
blood will be taken from the peripheral vein of the patient, Consent for publication
which significantly reduces the discomfort to the patient. Signed consent was obtained from the patient and

4. Conclusion guardians for the publication of patient-related test results
for this study.
We successfully performed a left tibial tumor resection and
implemented PCL/β-TCP/PRP bioprinting active bone Availability of data
implantation for the repair of bone defect. The wound Data will be made available on request.
recovered well after the operation, and we will continue to
follow up with the patient regularly to evaluate the clinical References
efficacy of the bioprinted active bone. This report presents 1. Roddy E, DeBaun MR, Daoud-Gray A, et al., 2018,
the first case of applying self-developed 3D-bioprinted Treatment of critical-sized bone defects: Clinical and tissue
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clinical practice in China.
https://doi.org/10.1007/s00590-017-2063-0
Acknowledgments 2. Li J, Lai Y, Li M, et al., 2022, Repair of infected bone

None. defect with clindamycin-tetrahedral DNA nanostructure
complex-loaded 3D bioprinted hybrid scaffold. Chem Eng J,
Funding 435: 134855.
https://doi.org/10.1016/j.cej.2022.134855
The authors thank the funding support from the General
program of NSFC (81972058) and Shanghai Key Clinical 3. Agarwal R, Garcia AJ, 2015, Biomaterial strategies for
Specialty Construction Project – Biomedical Materials engineering implants for enhanced osseointegration and
(shslczdzk06701), 3-year Action Plan of Shenkang bone repair. Adv Drug Deliv Rev, 94: 53–62.
Development Center (SHDC2020CR2019B), Huangpu https://doi.org/10.1016/j.addr.2015.03.013
District Industrial Support Fund (XK2020009) and 4. Kruyt MC, van Gaalen SM, Oner FC, et al., 2004, Bone
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Personalized Medicine (19DZ2250200), Shanghai Science
and Technology Commission Yangtze River Delta 5. Visscher DO, Farre-Guasch E, Helder MN, et al., 2016,
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Conflict of interest frontiers in bone bioprinting. Adv Healthc Mater, 8: 1801048.
The authors declare that they have no conflicts of interest. https://doi.org/10.1002/adhm.201801048
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platelet-rich plasma in alveolar distraction osteogenesis:
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Volume 9 Issue 2 (2023) 74 https://doi.org/10.18063/ijb.v9i2.654