Page 78 - IJB-9-2

International Journal of Bioprinting

CLINICAL CASE STUDY
The first 3D-bioprinted personalized active bone

to repair bone defects: A case report

Yongqiang Hao 1,2,3† *, Bojun Cao 1,2,3† , Liang Deng 1,2,3 , Jiaxin Li 1,2,3,4 , Zhaoyang Ran 1,2,3 ,
Junxiang Wu 1,2,3 , Boran Pang 1,2,3 , Jia Tan 1,2,3 , Dinghao Luo 1,2,3 , Wen Wu 1,2,3

1 Clinical and Translational Research Center for 3D Printing Technology, Shanghai Ninth People’s
Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China
2 Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai
Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011,
China
3 Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized
Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine,
Shanghai, 200011, China
4 Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin,
China
(This article belongs to the Special Issue: Novel Methods, Processes, and Materials of Bioprinting)

Abstract

The repair and reconstruction of bone defects are still major problems to be solved in
the field of orthopedics. Meanwhile, 3D-bioprinted active bone implants may provide
a new and effective solution. In this case, we used bioink prepared from the patient’s
† These authors contributed equally
to this work. autologous platelet-rich plasma (PRP) combined with polycaprolactone/β-tricalcium
phosphate (PCL/β-TCP) composite scaffold material to print personalized PCL/β-TCP/
*Corresponding authors: PRP active scaffolds layer by layer through 3D bioprinting technology. The scaffold
Yongqiang Hao
(hyq_9hospital@hotmail.com) was then applied in the patient to repair and reconstruct bone defect after tibial
tumor resection. Compared with traditional bone implant materials, 3D-bioprinted
Citation: Hao Y, Cao B, Deng L,
et al., 2023, The first 3D-bioprinted personalized active bone will have significant clinical application prospects due to its
personalized active bone to repair advantages of biological activity, osteoinductivity, and personalized design.
bone defects: A case report. Int J
Bioprint, 9(2): 654.
https://doi.org/10.18063/ijb.v9i2.654 Keywords: Bone defect; 3D bioprinting; Personalized active bone; Platelet-rich plasma
Received: October 23, 2022
Accepted: December 8, 2023
Published Online: December 22, 1. Background
2022
Bone defects caused by trauma, infection, tumor resection, and other factors are
Copyright: © 2022 Author(s). [1,2]
This is an Open Access article still a major problem that urgently needs to be solved in the field of orthopedics .
distributed under the terms of the Conventional treatment methods include autologous bone, allogeneic bone, or artificial
Creative Commons Attribution bone implantation, but these methods can only provide scaffold for the ingrowth of new
License, permitting distribution,
and reproduction in any medium, cells; the repair and regeneration of bone also require the ingrowth of macrophages,
provided the original work is osteoclasts, osteoblasts, and blood vessels, with the defects being completely replaced
properly cited. by new bone after crawling replacement, followed by reconstruction and shaping
Publisher’s Note: Whioce that ultimately completes the repair [3,4] . The traditional treatment method may lead
Publishing remains neutral with to increased risk of surgical traumas after autologous bone transplantation as well as
regard to jurisdictional claims in
published maps and institutional increased risk of infections transmitted by allogeneic bone transplantation and as a
affiliations. result of immune rejection. In addition, limited bone source is also another challenge

Volume 9 Issue 2 (2023) 70 https://doi.org/10.18063/ijb.v9i2.654