Page 102 - IJB-9-3

International Journal of Bioprinting

RESEARCH ARTICLE
The biological properties of 3D-printed

degradable magnesium alloy WE43 porous
scaffolds via the oxidative heat strategy

Shuyuan Min 1,2† , Chaoxin Wang 1,2† , Bingchuan Liu , Jinge Liu , Yu Liu ,
3
1,2
1,2
Zehao Jing , Yan Cheng , Peng Wen *, Xing Wang *, Yufeng Zheng , Yun Tian *
5
6
4
1,2
1,2
3
1 Department of Orthopedics, Peking University Third Hospital, Beijing 100191, People’s Republic
of China
2 Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing
100191, People’s Republic of China
3
Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China
4 Biomed-X Center, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing,
100871, China
5 Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of
Sciences, Beijing 100190, China
6 School of Materials Science and Engineering, Peking University, Beijing, 100871, China
(This article belongs to the Special Issue: Additive Manufacturing of Functional Biomaterials)
Abstract
† These authors contributed equally As a biodegradable material, magnesium alloy has a modulus similar to that of bone,
to this work.
and given the biological activity of its degradation products, it has the potential to
*Corresponding authors: be a bone grafting material. Oxidation heat treatment is a very effective passivation
Yun Tian (tiany@bjmu.edu.cn)
Peng Wen (wenpeng@tsinghua. method that may reduce the rate of magnesium alloy degradation. Oxidation
edu.cn) heat treatment increases the rare earth oxide content of the scaffold as well as
Xing Wang (wangxing@iccas.ac.cn) the corrosion resistance of the scaffold. The overall cytotoxicity of the as-printed
Citation: Min S, Wang C, Liu B, scaffolds (APSs) and oxidation heat-treated scaffolds (OHSs) showed that OHSs
et al., 2023, The biological accelerated cell proliferation. In the apoptosis experiment, the OHS group had a cell
properties of 3D-printed degradable survival rate between that of the control group and of the as-printed group. In the
magnesium alloy WE43 porous
scaffolds via the oxidative heat osteogenic induction experiment, the alkaline phosphatase activity and the quantity
strategy. Int J Bioprint, 9(3): 686. of mineralized nodules were greater in the APS and OHS groups than in the control
https://doi.org/10.18063/ijb.686 group. Marker proteins for bone growth were expressed at higher levels in the APS
Received: August 11, 2022 and OHS groups than in the control group. Therefore, oxidation heat-treated 3D
Accepted: November 08, 2022 printing scaffolds with good biocompatibility and osteogenic properties have great
Published Online: February 15,
2023 potential to be made into advanced biomaterials that can be used to fix bone defects.
Copyright: © 2023 Author(s).
This is an Open Access article Keywords: Oxidation heat; 3D printing; WE43 alloy; Magnesium alloy; Bone graft
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution
and reproduction in any medium,
provided the original work is 1. Introduction
properly cited.
[1]
Publisher’s Note: Whioce Over 2 million bone grafting surgeries are performed each year worldwide . While
Publishing remains neutral with autologous bone is universally recognized as the best bone graft option available, but
regard to jurisdictional claims in this technique can cause secondary trauma to the patient, and the allografts may cause
published maps and institutional [2]
affiliations. immunological rejection and increase the risk of infectious diseases . Therefore, it is

Volume 9 Issue 3 (2023) 94 https://doi.org/10.18063/ijb.686