Page 264 - IJB-9-3

International Journal of Bioprinting

RESEARCH ARTICLE
Research and analysis of the properties of

bredigite-based 3D-printed bone scaffolds

Dongxue Liu , Xuan Zhou , Fei Wang *, Yihua Feng , Yanbin Shi 1
2
1
1
1
1 Faculty of Mechanical Engineering, Qilu University of Technology (Shandong Academy of
Sciences), Jinan 250353, China
2 School of Intelligent Manufacturing Institute, Shandong University of Engineering and Vocational
Technology, Jinan 250353, China

Abstract

The use of bone tissue-engineered scaffolds for repairing bone defects has
become extremely common. Bone tissue-engineered scaffolds should have good
mechanical properties, a pore structure similar to that of natural bone, appropriate
biodegradability, and good biocompatibility to provide attachment sites for
growth factors and seed cells. They also need to exhibit special functions such as
osteoconductivity and osteoinduction. In this study, the mechanical, degradation,
and biological properties of bredigite were studied by using a triply periodic minimal
surface (TPMS) model structure. Pressure tests on bone tissue-engineered scaffolds
showed that the mechanical properties of TPMS scaffolds were significantly better
than those of open-rod scaffolds with the same porosity. By analyzing the biological
properties, we found that the TPMS model had better protein adsorption ability
than the open-rod model, the cells could better adsorb on the surface of the TPMS
scaffold, and the proliferation number and proliferation rate of the TPMS model were
higher than those of the open-ended rod model.
*Corresponding author:
Fei Wang (wf@qlu.edu.cn)
Keywords: Bone tissue-engineered scaffold; TPMS model; Porosity; Osteogenic
Citation: Liu D, Zhou X, Wang F, induction; Mechanical properties
et al., 2023, Research and analysis
of the properties of bredigite-based
3D-printed bone scaffolds.
Int J Bioprint, 9(3): 708.
https://doi.org/10.18063/ijb.708 1. Introduction
Received: September 05, 2022 The normal life of patients with bone defects can be severely affected since it takes a
Accepted: November 08, 2022
Published Online: March 14, 2023 long time for the bone tissue to self-heal and the large bone defects are not capable
of self-healing . To solve the problems caused by bone defects, a missing bone must
[1]
Copyright: © 2023 Author(s).
This is an Open Access article be replaced with an appropriate filler material [2-4] . Autologous, allogeneic, and tissue-
[5]
distributed under the terms of the engineered bones are the most common bone graft materials used in the medical field .
Creative Commons Attribution Autologous bone transplantation usually involves extended operation time and could
License, permitting distribution
and reproduction in any medium, aggravate patients’ pain as well as cause infection at bone extraction site, postoperative
[6]
provided the original work is discomfort, and other related complications . These factors also hinder the application
properly cited. of autologous bone grafting in repairing large bones . Owing to immune rejection,
[7]
Publisher’s Note: Whioce survival of donor’s bone cells in the patient cannot be guaranteed after allograft and the
Publishing remains neutral with bone disease would deteriorate further . However, bone tissue-engineered scaffolds are
[8]
regard to jurisdictional claims in
published maps and institutional not restricted by the antigenicity of allogeneic bones and the number of bone sources
affiliations. and thus, can be used in the clinical treatment of bone defects [9,10] .
Volume 9 Issue 3 (2023) 256 https://doi.org/10.18063/ijb.708