Page 228 - IJB-9-4
P. 228
International Journal of Bioprinting Simulation-based comparative analysis of nozzles for bioprinting
which is commonly used for bioprinting. Additionally, Consent for publication
pneumatic simulations were experimentally checked to Not applicable.
validate these computational models.
Both simulation and experimental results showed that Availability of data
the 3D printing nozzle can be used for bioprinting with
better performance than the 22G conical tip. Shear stress, Not applicable.
as the most relevant factor for cellular viability, has similar References
values, regardless of using either the 0.4 mm 3D printing
nozzle or the 22G conical tip. Additionally, the 3D printing 1. Cambridge dictionary, 2023, Bioprinting Definition, viewed
nozzle can halve the needed dispensing pressure while on January 23, 2023. (n.d.).
keeping the same volumetric flow, or it can increase the
volumetric flow, thus speeding up the bioprinting process https://dictionary.cambridge.org/es/diccionario/ingles/
bioprinting
while maintaining the dispensing pressure.
2. Ng WL, Chua CK, Shen YF, 2019, Print me an organ! Why
In future works, new simulations will be performed we are not there yet. Progr Polym Sci, 97:101145.
to study the inner geometry variations in the 3D printing https://doi.org/10.1016/j.progpolymsci.2019.101145
nozzles and to assure if the standard 3D printing nozzle
has better performance than that with similar output 3. Li S, Liu S, Wang X, 2022, Advances of 3D printing in
diameters/gauges conical tips. vascularized organ construction. Int J Bioprint, 8(3):588.
https://doi.org/10.18063/ijb.v8i3.588
Acknowledgments 4. Pedroza-González SC, Rodriguez-Salvador M, Pérez-Benítez
None. BE, et al., 2021, Bioinks for 3D bioprinting: A scientometric
analysis of two decades of progress. Int J Bioprint, 7(2):337.
Funding https://doi.org/10.18063/ijb.v7i2.337
This study was supported by Junta de Extremadura, 5. Ng WL, Lee JM, Zhou M, et al., 2020, Vat polymerization-
Consejería de Economía, Ciencia y Agenda Digital based bioprinting—Process, materials, applications and
regulatory challenges. Biofabrication, 12(2):022001.
[PD16067, IB16200, IB20158 (2021/00110/001),
GR21201], cofunded by European Union (ERDF “A way https://doi.org/10.1088/1758-5090/ab6034
to make Europe”), by the Interreg V A Spain - Portugal 6. Ozbolat IT, Hospodiuk M, 2016, Current advances and
(POCTEP) 2014-2020 program [0633_BIOIMPACE_4_A] future perspectives in extrusion-based bioprinting.
Biomaterials, 76:321–343.
Conflict of interest https://doi.org/10.1016/j.biomaterials.2015.10.076
The authors declare no conflict of interests. 7. Yilmaz B, Al Rashid A, Mou YA, et al., 2021, Bioprinting: A
review of processes, materials and applications. Bioprinting,
Author contributions 23:e00148.
Conceptualization: Juan Carlos Gómez-Blanco, J. Blas Pagador https://doi.org/10.1016/j.bprint.2021.e00148
Formal analysis: Juan Carlos Gómez-Blanco, Luisa F. 8. Li Q, Zhang B, Xue Q, et al., 2021, A systematic thermal analysis
Sánchez-Peralta for accurately predicting the extrusion printability of alginate-
Funding acquisition: Juan Carlos Gómez-Blanco, J. Blas gelatin-based hydrogel bioinks. Int J Bioprint, 7(3):394.
Pagador, Francisco M. Sánchez-Margallo https://dx.doi.org/10.18063/ijb.v7i3.394
Investigation: Juan Carlos Gómez-Blanco, Manuel 9. Fu E, Wentland L, 2022, A survey of 3D printing technology
Matamoros, Alfonso Marcos, Victor P. Galván- applied to paper microfluidics. Lab Chip, 22(1):9–25.
Chacón, J. Blas Pagador
Methodology: Juan Carlos Gómez-Blanco, J. Blas Pagador https://doi.org/10.1039/D1LC00768H
Writing – original draft: Juan Carlos Gómez-Blanco 10. Li X, Liu B, Pei B, et al., 2020, Inkjet bioprinting of
Writing – review & editing: Manuel Matamoros, Luisa F. biomaterials. Chem Rev, 120(19):10793–10833.
Sánchez-Peralta, Victor P. Galván-Chacón, J. Blas https://doi.org/10.1021/acs.chemrev.0c00008
Pagador 11. Heinrich MA, Liu W, Jimenez A, et al., 2019, 3D bioprinting:
From benches to translational applications. Small,
Ethics approval and consent to participate 15(23):1805510.
Not applicable. https://doi.org/10.1002/smll.201805510
Volume 9 Issue 4 (2023) 220 https://doi.org/10.18063/ijb.730

