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International Journal of Bioprinting 3D printing in bone regeneration and bone repair

Figure 6. Mapping of publications and references for studies on three-dimensional printing in bone regeneration and bone repair. (A) Network map of
citation analysis for documents with more than 25 citations. (B) Network map of the co-citation analysis of references based on CiteSpace. (C) Clustering
analysis of the co-citation network based on CiteSpace.

4.2. Research hotspots and frontiers “finite element analysis” as important research hotspots
The co-occurrence analysis of keywords and burst appearances deserves further attention. The digital light processing
reflected research hotspots of 3DP in bone repair and (DLP) method has been considered an attractive 3DP
regeneration. The co-occurrence network of keywords, which approach because it can fabricate a single layer of 3D
reflected keyword appearance in the titles/abstracts of all scaffold through spatially controlled solidification using
included publications, was divided into four main categories: a projector light . Notably, DLP has been developed to
[37]
“3DP techniques,” “3DP materials,” “bone regeneration,” and produce BTE scaffolds with highly interconnected pore
“bone disease therapeutics.” The research related to these four architectures. For example, a recent study has developed
groups of keywords not only represents current hotspots in bioceramic scaffolds mimicking the Haversian bone
the field but also forecasts the direction of future studies. structure using DLP-based 3DP, demonstrating the ability
to increase blood vessel ingrowth and bone formation .
[38]
4.2.1. 3DP techniques Moreover, computational methods, including finite
The co-occurrence analysis of keywords identifying element analysis, have been used to assist biomimetic
“digital light processing,” “additive manufacturing,” and modeling of 3DP scaffolds. For example, computational

Volume 9 Issue 4 (2023) 325 https://doi.org/10.18063/ijb.737