Page 479 - IJB-9-5
P. 479
International Journal of Bioprinting 3D printed hydrogel for infected wound healing via PDT
for wound dressings. We also characterized the printability Consent for publication
of MB@UiO-66(Ce)/PH hydrogel and improved the Not applicable.
mechanical properties of the hydrogel using nanoparticles.
At the same time, the hydrogels were shown to have Availability of data
good biocompatibility and to promote early cell adhesion
and migration. This 3D-bioprinted dressing also has The data underlying this article will be shared on reasonable
antibacterial properties from the PDT effect of MB@UiO- request to the corresponding author.
66(Ce) NPs and promotes the healing of infected wounds.
With a 20-min laser irradiation treatment, the MB@UiO- References
66(Ce)/PH significantly reduced the viability of S. aureus
and E. coli. The antibacterial capacity of the hydrogels 1. Kechichian E, Ezzedine K, 2018, Vitamin D and the skin:
increased with the concentration of NPs. Meanwhile, after An update for dermatologists. Am J Clin Dermatol, 19:
a 7-day treatment with PH-1, the full-thickness skin defects 223–235.
in mice were repaired, and the hydrogels showed better 2. Falcone M, De Angelis B, Pea F, et al., 2021, Challenges
healing effects. In conclusion, the prepared 3D-bioprinted in the management of chronic wound infections. J Global
composite photo-crosslinked MB@UiO-66(Ce)/PH with Antimicrob Resist, 26: 140–147.
good antibacterial properties and tissue healing-promoting 3. Kathawala MH, Ng WL, Liu D, et al., 2019, Healing of
ability provides a new strategy involving 3D bioprinting for chronic wounds: An update of recent developments and
preparing wound dressings. future possibilities. Tissue Eng Part B Rev, 25: 429–444.
Acknowledgments 4. Simoes D, Miguel SP, Ribeiro MP, et al., 2018, Recent
advances on antimicrobial wound dressing: A review. Eur J
None. Pharm Biopharm, 127: 130–141.
5. Yang N, Zhu M, Xu G, et al., 2020, A near-infrared light-
Funding responsive multifunctional nanocomposite hydrogel for
This research was funded by the National Natural efficient and synergistic antibacterial wound therapy and
Science Foundation of China (Nos. 82100963, 82270953 healing promotion. J Mater Chem B, 8: 3908–3917.
and 81971840), Shanghai Rising-Star Program 6. White RJ, Cutting K, Kingsley A, 2006, Topical antimicrobials
(21QA1405400), and Natural Science Foundation of in the control of wound bioburden. Ostomy/Wound Manage,
Shanghai (22ZR1436400). 52: 26–58.
7. Zhao G, Hochwalt PC, Usui ML, et al., 2010, Delayed
Conflict of interest wound healing in diabetic (db/db) mice with Pseudomonas
The authors declare they have no competing interests. aeruginosa biofilm challenge: A model for the study of
chronic wounds. Wound Repair Regen, 18: 467–477.
Author contributions 8. Li S, Dong S, Xu W, et al., 2018, Antibacterial hydrogels. Adv
Sci, 5: 1700527.
Conceptualization: Wei Wang, Yang Liu, Chen Wang
Formal analysis: Zhuoyuan Li, Ao Zheng, Zhiyuan Mao 9. Dai X, Zhao Y, Yu Y, et al., 2017, Single continuous near-
Investigation: Zhuoyuan Li, Ao Zheng infrared laser-triggered photodynamic and photothermal
Methodology: Zhuoyuan Li, Ao Zheng, Fupeng Li, Tingshu Su ablation of antibiotic-resistant bacteria using effective
Writing – original draft: Zhuoyuan Li, Ao Zheng, Lingyan targeted copper sulfide nanoclusters. ACS Appl Mater
Interfaces, 9: 30470–30479.
Cao, Tingshu Su
Writing – review & editing: Wei Wang, Yang Liu, Chen 10. Van Vlierberghe S, Dubruel P, Schacht E, 2011, Biopolymer-
Wang based hydrogels as scaffolds for tissue engineering
applications: A review. Biomacromolecules, 12: 1387–1408.
Ethics approval and consent to participate 11. Bilici C, Can V, Nöchel U, et al., 2016, Melt-processable
All experimental protocols in the study were conducted shape-memory hydrogels with self-healing ability of high
mechanical strength. Macromolecules, 49: 7442–7449.
according to the guidelines of the Declaration of Helsinki
and approved by the Institutional Ethics Committee of 12. Tavakoli S, Klar AS, 2020, Advanced hydrogels as wound
Shanghai Ninth People’s Hospital, Shanghai Jiao Tong dressings. Biomolecules, 10: 1169.
University School of Medicine (SH9H-2021-A32-1). All 13. Koehler J, Brandl FP, Goepferich AM, 2018, Hydrogel
methods were carried out in accordance with relevant wound dressings for bioactive treatment of acute and
guidelines and regulations. chronic wounds. Eur Polym J, 100: 1–11.
Volume 9 Issue 5 (2023) 471 https://doi.org/10.18063/ijb.773

