Page 51 - IJB-9-5

International Journal of Bioprinting Precise fabrication of engineered vascular networks

Figure 4. Vasculature density effect on swelling compensation. (A) Designed vasculature patterns with different densities. (B) Images of P/G hydrogel
3
constructs with different vasculature densities at different shrinking time points. (C, D, and E) Diameter of printed sacrificial F-127 fibers and vasculature
at different shrinking time points for P/G , P/G , and P/G hydrogel constructs, respectively. (F, G, and H) Shrinkage ratio of P/G , P/G , and P/G hydrogel
3
2
4
3
2
4
scaffolds with different vasculature densities, respectively. n = 3 for each group.
in Figures S3 and S4 (Supplementary File). The diameter scaffolds was computed and is shown in Figure 4F–H,
of the fibers in sacrificial templates and the vasculature in respectively. The results showed that the vasculature with
P/G , P/G , and P/G hydrogel scaffolds before and after different densities has the same trend of swelling and
3
4
2
shrinking were recorded in Figure 4C–E, respectively. volume shrinkage behaviors. Specifically, the diameter
The shrinkage ratio of P/G , P/G , and P/G hydrogel of the vasculature after shrinking for 2 h decreased upon
2 3 4
Volume 9 Issue 5 (2023) 43 https://doi.org/10.18063/ijb.749