Page 48 - IJB-9-6

International

Journal of Bioprinting

RESEARCH ARTICLE
Sub-regional design of the bionic bone scaffolds

using macrostructural topology

Yangdong He 1,2† , Long Chao 1,2† , Chen Jiao , Hong Wang , Deqiao Xie ,
1
1
1,2
Guofeng Wu , Lin Wang , Changjiang Wang , Jianfeng Zhao *, Lida Shen *,
1,2
4
3
1,2
5
and Huixin Liang *
6,7
1 Institute of Additive Manufacturing (3D Printing), Nanjing University of Aeronautics and Astronautics,
Nanjing, 210016, China
2 Jiangsu Key Laboratory of Digital Medical Equipment Technology, Nanjing University of Aeronautics
and Astronautics, Nanjing, 210016, China
3
Stomatological Digital Engineering Center, Nanjing Stomatological Hospital, Nanjing, 210008,
China
4 Nanjing Chamlion Laser Technology Co., Ltd, Nanjing, 210012, China
5 Department of Engineering and Design, University of Sussex, Brighton, BN1 9RH, United Kingdom
6 State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult
Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The
Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China
7 Jiangsu Engineering Research Center for 3D Bioprinting, Nanjing, 210008, China
† These authors contributed equally
to this work.
*Corresponding authors:
Jianfeng Zhao
(zhaojf@nuaa.edu.cn) Abstract
Lida Shen
(ldshen@nuaa.edu.cn) With the increasing demand for bone repair, the bionic bone scaffolds have become
Huixin Liang a research hotspot. A sub-regional design method of the bionic bone scaffolds, using
(hxliang@nuaa.edu.cn) macrostructural topology, is proposed in this paper, aiming to provide a functionally
Citation: He Y, Chao L, Jiao C, enhanced region division method for the gradient design. The macrostructural
et al., 2023, Sub-regional design topology was carried out by the bi-directional evolutionary structural optimization
of the bionic bone scaffolds using (BESO), dividing the predefined design domain into sub-region A and sub-region B.
macrostructural topology. Int J
Bioprint, 9(6): 0222. Subsequently, a combined probability sphere model and a distance-to-scale
https://doi.org/10.36922/ijb.0222 coefficient mapping model are established to implement the graded porosification
Received: October 07, 2022 based on the Voronoi tessellation. This approach takes geometric and mechanical
Accepted: November 11, 2022 continuity into fully account and assures a reasonable distribution of characteristic
Published Online: June 27, 2023 parameters, yielding to improve the mechanical strength under specific stress
Copyright: © 2023 Author(s). conditions. Finally, the scaffolds were fabricated by the laser powder bed fusion (LPBF)
This is an Open Access article process using the Ti-6Al-4V powder. The results of compression tests are satisfactory,
distributed under the terms of the showing that the as-built specimens implement sub-regional functionality. The
Creative Commons Attribution
License, permitting distribution, apparent elastic modulus and the ultimate strength range, respectively, between
and reproduction in any medium, 1.50 GPa and 7.12 GPa (for the first module) and between 38.55 MPa and 268.03 MPa
provided the original work is (for the second module), which conform to the required level of natural bone,
properly cited.
providing a possibility for clinical application.
Publisher’s Note: AccScience
Publishing remains neutral with
regard to jurisdictional claims in Keywords: Functionally graded porous materials; Bionic scaffolds; Bi-directional
published maps and institutional
affiliations. evolutionary structural optimization; Voronoi tessellation; Laser powder bed fusion

Volume 9 Issue 6 (2023) 40 https://doi.org/10.36922/ijb.0222