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International Journal of Bioprinting Advances for 3D-printed oral drug delivery systems

Figure 7. Type of dosage form per 3D printing technique of the categories “end-user applications,” “quality assurance,” “user acceptability,” and “digital
technologies.” *Specific technique not available.

identified, which should be reduced or eliminated before release 3D-printed budesonide tablet. The tablets were
clinical assessment . printed using semi-solid extrusion with a CraftMake™ 3D
[37]
printer. The results revealed excellent and significant dose
To improve antitumor activity, tumor targetability, and [40]
safety for the treatment of colon cancer, Mirdamadian et al. accuracy and quality .
merged fused deposition modeling and nanotechnology Oral premalignant lesions can lead to oral cancer. Liu
to produce a 3D-printed tablet loaded with oxaliplatin et al. developed non-invasive 3D-printed mucoadhesive
alginate nanoparticles . The 3D-printed tablets had a patches loaded with oxaliplatin and mycophenolate. The
[38]
remarkable antitumor effect and safety profile .
[38]
patch exhibited sustained release, significant ablation to
Intestinal alkaline phosphatase can regulate intestinal dysplastic lesions, and minimal side effects . Tagami
[41]
inflammation and treat ulcerative colitis, an inflammatory et al. also created a mucoadhesive film using a pressure-
bowel disease; nonetheless, its intraduodenal assisted microsyringe. The film was loaded with ibuprofen/
administration is not convenient. Nguyen et al. fabricated lidocaine ionic liquid to treat oral mucositis caused by
powder bed-printed coated tablets loaded with alkaline radiation therapy and chemotherapy . During the same
[42]
phosphatase and a coating of PEG 1500 . The results year, alternatives for the treatment of oral leukoplakia were
[39]
showed a controlled release profile and ileocolonic targeted evaluated. Here, Takashima et al. developed an apigenin-
activity. The 3D-printed tablets help avoid the degradation loaded mucoadhesive oral film, but with a different
of alkaline phosphatase and help selective delivery to 3D printing process, in this case semi-solid extrusion,
the colon . In 2023, due to the limits of commercial and it was designed to avoid surgical removal. The film
[39]
formulations for the treatment of inflammatory bowel demonstrated a remarkable chemopreventive effect, which
disease, Ou et al. produced an adjustable and controlled may be of great help to prevent oral carcinogenesis .
[43]

Volume 9 Issue 6 (2023) 510 https://doi.org/10.36922/ijb.1119