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Conceptualization: Juan Liu, Yunfang Wang, toxicology-applications & advantages. Environ Int.
Xiangdong Kong 2024;184:108415.
Data curation: Yinpeng Le, Tanqing Long, Mingyue Pan, doi: 10.1016/j.envint.2024.108415
Qingru Song 8. Bock C, Boutros M, Camp JG, et al. The organoid cell atlas.
Formal analysis: Yinpeng Le, Tanqing Long, Wenrui Ma, Nat Biotechnol. 2021;39(1):13-17.
Yuxin Su doi: 10.1038/s41587-020-00762-x
Supervision: Yunfang Wang, Xiangdong Kong
Visualization: Juan Liu, Yinpeng Le, Mengcheng Tang 9. Park SB, Kim EA, Kim KY, Koh, B. Induction of toxicity in
Writing–original draft: Juan Liu, Yinpeng Le human colon cells and organoids by size- and composition-
dependent road dust. RSC Adv. 2023;13(5):2833-2840.
Writing–review & editing: Yinpeng Le, Tanqing Long, doi: 10.1039/D2RA07500H
Qi Wang, Wenrui Ma, Yuxin Su, Juan Liu, YuTian
Feng, Ni An, Wenzhen Yin 10. Vinken M, Grimm D, Baatout S, et al. Taking the 3Rs
All authors read and approved the final manuscript. to a higher level: replacement and reduction of animal
testing in life sciences in space research. Biotechnol Adv.
Ethics approval and consent to participate 2025;81:108574.
doi: 10.1016/j.biotechadv.2025.108574
Not applicable. 11. Markets and Markets. In Vitro Toxicology Testing Market
Growth, Drivers, And Opportunities. MarketsandMarkets;
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Not applicable. https://www.marketsandmarkets.com/ Market-Reports/ in-
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