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A. Ebrahimzadeh, R. Khanduzi, A. Jajarmi / IJOCTA, Vol.15, No.2, pp.294-310 (2025)
            Table 1. Categorization of pertinent studies on multi-strain COVID-19 models published in the literature

                    Paper       Model      Data       Solution Approach             Vaccination  Multi-Strain
                    [9]         SEIQRDV    Saudi Arabia Ensemble Kalman Filter      ✓        ✗
                    [10]        SEIQR      Pakistan   Pontryagin’s Maximum Principle  ✗      ✗
                    [11]        SEIARQD    Nigeria    Pontryagin Maximum Principle  ✗        ✗
                    [12]        SS q EIQAHR  Malaysia  Fourth Order Runge-Kutta Method  ✗    ✗
                    [13]        SIR        China      Runge-Kutta-Fehlberg method   ✓        ✗
                    [14]        SVEIR      Pakistan   Pontryagin Maximum Principle  ✓        ✗
                    [15]        SEAIR      Pakistan   Forward-backward Runge-Kutta method  ✓  ✗
                    [17]        SEVI u I I R u R k  India  Pontryagin Maximum Principle  ✓   ✗
                    [18]        SEIR       England    Pontryagin Maximum Principle  ✓        ✓
                    [19]        SIR        Unknown    Pontryagin Maximum Principle  ✓        ✓
                    [20]        SVI s I v R  Morocco  Pontryagin Maximum Principle  ✓        ✓
                    [21]        SIR        Unknown    Stochastic Maximum Principle  ✓        ✓
                    [22]        SLIHQR     UK         Pontryagin Maximum Principle  ✓        ✓
                    [23]        SEAIGRD    India      Pontryagin Maximum Principle  ✓        ✓
                    Current Paper SVI c I v R  Morocco  Collocation method and FBMO  ✓       ✓


            numerical accuracy, and facilitating straightfor-  of the local approaches used to solve large-scale
            ward implementation when addressing complex       nonlinear optimization problems because they are
            systems. Alternatively, the sparse derivative op-  efficient. 24–26  However, they get local solutions in
            erational matrix approximates the derivative La-  a high running time as the problem dimension in-
            guerre vector, significantly boosting the compu-  creases. To prevent these types of defects, a meta-
            tational process’s reliability and efficiency. The  heuristic algorithm called FBMO is developed in
            rationale behind selecting Laguerre polynomials   this paper.  The efficacy of FBMO in making
            as a basis for the approximations is as follows:  high decisions and global searches are some of
                 1- Laguerre polynomials are orthogonal con-  the benefits of using FBMO to solve the con-
                    cerning the exponential weight function   verted OCP of the multi-strain COVID-19 model
                            −t
                    ω(t) = e , which naturally aligns with    in the form of an NLP. More to the point, the
                    problems involving decaying processes     FBMO is among the newly published prosperous
                    over time.  This property ensures sta-    metaheuristic methods that attracted the inter-
                    bility and precision in approximating our  est of various authors in this short period of one
                                                                   27–32
                    model’s state and control variables.      year.     Indeed, the FBMO is a nature-inspired
                 2- Expanding functions in terms of Laguerre  optimization method that simulates the regular
                    polynomials facilitates the reduction of  movement and flow processes of water masses
                    the infinite-dimensional OCP to a finite-  throughout the flooding phenomenon in nature.
                    dimensional system.   This significantly  It obtains near-optimal answers or the global
                    reduces computational complexity while    minimum of NLPs efficiently. About the novel
                    preserving high accuracy.                 FBMO, it should be noted that this approach
                                                              is efficient and robust, significantly when solving
                 3- Laguerre polynomials have sparse deriva-                               27
                    tive operational matrices, which makes it  large-sized instances of NLPs.  Comparing the
                    easier to solve the NLP that comes from   FBMO algorithm with some recent metaheuristic
                    the OCP.                                  methods is a noteworthy comparison, after which
                 4- Several OCPs have been successfully       the performance of the FBMO is well-appraised
                    solved using Laguerre-based collocation   compared to benchmark functions and engineer-
                                                                           27–32
                    methods. This shows that they work well   ing problems.     The assessment of the FBMO’s
                    and are reliable when using computers     results assimilates four statistical metrics: mean,
                    to deal with constraints and dynamics in  best, standard deviation, and average Friedman
                    complex systems.                          rank. These values are considered for ranking the
                                                              metaheuristic methods concerning each bench-
                Because of these features, Laguerre polynomi-
                                                              mark function and engineering problem. These
            als were chosen as the best way to turn the OCP of
                                                              criteria show that the FBMO provided highly
            the multi-strain COVID-19 model into a solvable
                                                              competitive solutions compared to some modern
            NLP. This facilitated the rapid and accurate iden-  metaheuristic methods. 27–32  Therefore, we have
            tification of the most effective control strategies.
                                                              proven that the FBMO is a suitable approach for
                Since the converted OCP for the multi-strain
                                                              our NLP problem.
            COVID-19 is a large-scale NLP, we should select
            efficient local and metaheuristic methods to solve    The proposed hybrid strategy, combining the
            this optimization problem. Conjugate gradient,    collocation method with the FBMO, offers several
            trust-region, and quasi-Newton methods are some   key advantages:
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