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Innovative Medicines & Omics Fermentation in dermatology

the skin. 88 L . rhamnosus is a probiotic known to enhance Author contributions
the intestinal barrier’s performance and is anticipated to
be used in cosmetics. Research has indicated that topical Conceptualization: Rawan Atef Essmat, Radwa Abdallnasser
89
application of L. rhamnosus lysate to a human epidermal Writing-original draft: Rawan Atef Essmat, Nour Altalla
model for 16 days increased the expression of skin barrier Writing-review & editing: Radwa Abdallnasser
proteins and promoted SC formation, which may have Ethics approval and consent to participate
beneficial effects in preserving skin barrier function.
90
Although more investigation is necessary, these results imply Not applicable.
that topical probiotics could have potential applications in Consent for publication
skincare products. In addition, L. rhamnosus showed a high
inhibition of tyrosinase and melanin synthesis and increased Not applicable.
collagen production when co-cultured with L. paracasei.
91
Besides the mentioned microorganisms and metabolites, Availability of data
there are many other examples of microorganism-derived Not applicable.
metabolites affecting the skin, as shown in Table 3.
References
4. Conclusion
1. Zofia NŁ, Aleksandra Z, Tomasz B, et al. Effect of fermentation
FPEs are superior among the reviewed skincare time on antioxidant and anti-ageing properties of green
ingredients, due to their increased biological activity and coffee kombucha ferments. Molecules. 2020;25(22):5394.
varied benefits. In these extracts, fermentation enhances doi: 10.3390/molecules25225394
anti-inflammatory, antibacterial, and antioxidant 2. Ramadhania ZM, Yang DU, Moektiwardojo M, et al.
properties, and accelerates wound-healing processes, Enhanced anti-skin aging effects of fermented black ginseng
making these fermented extracts more potent than their (Panax ginseng CA Meyer) by Aspergillus niger KHNT-1.
non-fermented counterparts. For example, fermented Appl Sci. 2022;13(1):550.
P. ginseng is remarkably effective in anti-aging and doi: 10.3390/app13010550
skin whitening, while fermented M. denudata and rice
bran have significant antioxidant and skin-brightening 3. Corbu VM, Gheorghe-Barbu I, Dumbrava AS,
properties. Fermentation enhances the bioavailability of Vrâncianu CO. Current insights in fungal importance-a
bioactive phytochemicals toward better skin hydration, comprehensive review. Microorganisms. 2023;11:1384.
collagen synthesis, and barrier function. The integration of doi: 10.3390/microorganisms11061384
microorganisms and their metabolites in skincare products 4. Ragusa I, Nardone GN, Zanatta S, Bertin W, Amadio E.
highlights the tendency of industry productions to shift Spirulina for skin care: A bright blue future. Cosmetics.
toward more advanced natural solutions. Probiotic strains, 2021;8:7.
including N. eutropha, E. faecalis, and V. filiformis, impart doi: 10.3390/cosmetics8010007
beneficial properties such as skin texture improvement,
anti-inflammation, and barrier support. Fermented acids, 5. Liu Z, Liu X, Ma Z, Guan T. Phytosterols in rice bran and
vitamins, and amino acids enhance the functionality of their health benefits. Front Nutr. 2023;10:1287405.
ingredients, thereby increasing hydration, skin lightening, doi: 10.3389/fnut.2023.1287405
and exfoliation. These advancements within fermentation 6. Sourabh A, Rai AK, Chauhan A, et al. Health related
technology would enable the development of innovative issues and indigenous fermented products. In: Indigenous
skincare products, offering better and more sustainable fermented foods of South Asia. Vol. 7. United States: CRC
solutions for achieving healthier, brighter skin. Press; 2015. p. 309.
7. Hrubša M, Siatka T, Nejmanová I, et al. Biological properties
Acknowledgments of vitamins of the B-complex, part 1: Vitamins B , B , B , and
1
3
2
None. B . Nutrients. 2022;14(3):484.
5
doi: 10.3390/nu14030484
Funding
8. Stavrakidis KKS. Probiotics: Benefits on Skin Health and
None. Therapeutical Potential. Doctoral dissertation, University of
Rijeka; 2024.
Conflict of interest
9. Zhao YS, Eweys AS, Zhang JY, et al. Fermentation affects the
The authors declare they have no competing interests. antioxidant activity of plant-based food material through

Volume 2 Issue 1 (2025) 30 doi: 10.36922/imo.5020