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Innovative Medicines & Omics Fermentation in dermatology
Table 2. Amino acids and their respective beneficial compounds for skin health
Amino Chemical structure Microbes involved Function on skin Description of benefits
acid
L-glutamic Staphylococcus epidermidis, Functions as a moisturizer L-glutamic acid helps retain moisture and
Corynebacterium spp. promotes hydration maintain the skin’s natural hydration barrier. 38
L-arginine Cutibacterium acnes, Acts as an antioxidant, L-arginine plays a role in collagen synthesis,
Staphylococcus spp. promotes wound healing supporting wound repair and skin elasticity. 39
L-serine Staphylococcus spp., Hydrates skin, maintains L-serine is essential for skin hydration and
Micrococcus luteus elasticity softness, contributing to the skin’s natural
moisturizing factor. 71
L-alanine Staphylococcus epidermidis, Strengthens skin barrier, L-alanine provides hydration and supports
Corynebacterium spp. enhances moisture retention the skin barrier, helping protect against
environmental stress. 44
L-proline Cutibacterium acnes, Synthesizes collagen, improves L-proline aids in collagen formation, enhancing
Corynebacterium spp. skin texture skin firmness and reducing the appearance of
fine lines. 72
L-lysine Cutibacterium acnes, Acts as an anti-inflammatory L-lysine contributes to collagen formation,
Staphylococcus aureus agent, supports skin repair aids in wound healing and inflammation
reduction. 73
L-glycine Corynebacterium spp., Provides hydration, enhances L-glycine supports collagen production,
Micrococcus luteus skin texture maintains hydration, and improves overall skin
texture. 74
L-histidine Staphylococcus epidermidis, Acts as an antioxidant, L-histidine is an antioxidant that hydrates the
Corynebacterium spp. enhances moisture retention skin, promoting softness and resilience. 75
L-tyrosine Propionibacterium acnes, Regulates skin pigmentation L-tyrosine is a pre-cursor for melanin synthesis,
Staphylococcus spp. regulates pigmentation, and protects against UV
radiation. 76
L-cysteine Cutibacterium acnes, Acts as an antioxidant, L-cysteine helps with collagen production and
Staphylococcus aureus supports skin healing provides antioxidant protection, aiding skin
regeneration. 77
Abbreviation: UV: Ultraviolet.
after using these ingredients as food for more than N. eutropha is an ammonia-oxidizing bacterium that
1,300 years. It is anticipated that fermented cosmetics oxidizes sweat-derived ammonia to create nitric oxide and
will continue to expand as a category of products in the nitrogen on the skin. Clinical trials on topical treatment
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natural skincare product market and offer many health of N. eutropha showed improvement in pigmentation and
benefits. 78 wrinkles between the eyebrows and on the forehead. This
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Volume 2 Issue 1 (2025) 28 doi: 10.36922/imo.5020
