Page 75 - IMO-2-1
P. 75
Innovative Medicines & Omics Flavonoids against glycosidic hydrolase
doi: 10.1016/j.chmed.2018.08.010 UHPLC-QTOF-MS/MS combined plant metabolomics
and spectrum-effect relationship analyses. Food Funct.
17. Wu X, Hu M, Hu X, et al. Inhibitory mechanism of
epicatechin gallate on α-amylase and α-glucosidase and 2022;13(19):10291-10304.
its combinational effect with acarbose or epigallocatechin doi: 10.1039/d2fo00562j
gallate. J Mol Liq. 2019;290:111202.
27. Zhang J, Chen T, Li K, et al. Screening active ingredients of
doi: 10.1016/j.molliq.2019.111202 rosemary based on spectrum-effect relationships between
UPLC fingerprint and vasorelaxant activity using three
18. Yang J, Wang X, Zhang C, et al. Comparative study of
inhibition mechanisms of structurally different flavonoid chemometrics. J Chromatogr B Analyt Technol Biomed Life
compounds on alpha-glucosidase and synergistic effect with Sci. 2019;1134-1135:121854.
acarbose. Food Chem. 2021;347:129056. doi: 10.1016/j.jchromb.2019.121854
doi: 10.1016/j.foodchem.2021.129056 28. Zhang D, Liu X, Yang Z, et al. Interactions between phenols
and alkylamides of Sichuan Pepper (Zanthoxylum genus)
19. Guo S, Meng J, Wang S, et al. Preparation of magnetic
microcapsules of α-amylase and α-glucosidase for dual- in alpha-glucosidase inhibition: A structural mechanism
target affinity screening of active components from Toona analysis. J Agric Food Chem. 2021;69(20):5583-5598.
sinensis. Process Biochem. 2023;124:92-99. doi: 10.1021/acs.jafc.1c00741
doi: 10.1016/j.procbio.2022.11.018 29. Aleixandre A, Gil JV, Sineiro J, et al. Understanding
phenolic acids inhibition of α-amylase and α-glucosidase
20. Wang R, Fan R, Meng T, et al. Exploration of the inhibitory
mechanisms of trans-polydatin/resveratrol on α-glucosidase and influence of reaction conditions. Food Chem.
by multi-spectroscopic analysis, in silico docking and 2022;372:131231.
molecular dynamics simulation. Spectrochim Acta A Mol doi: 10.1016/j.foodchem.2021.131231
Biomol Spectrosc. 2023;299:122866.
30. Lim J, Ferruzzi MG, Hamaker BR. Structural requirements
doi: 10.1016/j.saa.2023.122866 of flavonoids for the selective inhibition of alpha-amylase
versus alpha-glucosidase. Food Chem. 2022;370:130981.
21. Wang D, Gu X, Fang K, et al. Study on quality control of
Zuojin pill by HPLC fingerprint with quantitative analysis of doi: 10.1016/j.foodchem.2021.130981
multi-components by single marker method and antioxidant 31. Wang S, Li Y, Huang D, et al. The inhibitory mechanism
activity analysis. J Pharm Biomed Anal. 2023;225:115075.
of chlorogenic acid and its acylated derivatives on alpha-
doi: 10.1016/j.jpba.2022.115075 amylase and α-glucosidase. Food Chem. 2022;372:131334.
22. Li C, Cui Y, Lu J, et al. Spectrum-effect relationship of doi: 10.1016/j.foodchem.2021.131334
immunologic activity of Ganoderma lucidum by UPLC-MS/ 32. Ghani U, Nur-e-Alam M, Yousaf M, Ul-Haq Z, Noman OM,
MS and component knock-out method. Food Sci Hum Al-Rehaily AJ. Natural flavonoid α-glucosidase inhibitors
Wellness. 2021;10(3):278-288.
from Retama raetam: Enzyme inhibition and molecular
doi: 10.1016/j.fshw.2021.02.019 docking reveal important interactions with the enzyme
active site. Bioorg Chem. 2019;87:736-742.
23. Chen Y, Pan G, Xu W, et al. Spectrum-effect relationship
study between HPLC fingerprints and antioxidant activity doi: 10.1016/j.bioorg.2019.03.079
of Sabia parviflora. J Chromatogr B Analyt Technol Biomed 33. Wang Y, Zhang G, Pan J, et al. Novel insights into the
Life Sci. 2020;1140:121970.
inhibitory mechanism of kaempferol on xanthine oxidase.
doi: 10.1016/j.jchromb.2020.121970 J Agric Food Chem. 2015;63(2):526-534.
24. Zhao Y, Wang M, Huang G. Structure-activity relationship doi: 10.1021/jf505584m
and interaction mechanism of nine structurally similar 34. Hua F, Zhou P, Wu HY, et al. Inhibition of α-glucosidase and
flavonoids and α-amylase. J Funct Foods. 2021;86:104739.
α-amylase by flavonoid glycosides from Lu’an GuaPian tea:
doi: 10.1016/j.jff.2021.104739 Molecular docking and interaction mechanism. Food Funct.
2018;9(8):4173-4183.
25. Wu H, Lv Y, Wei F, Li C, Ge W, Du W. Comparative analysis of
anti-osteoporosis efficacy in Radix Dipsaci before and after doi: 10.1039/c8fo00562a
processing with salt based on spectrum-effect relationship. 35. Wu Y, Han Z, Wen M, et al. Screening of α-glucosidase
J Pharm Biomed. 2022;221:115078.
inhibitors in large-leaf yellow tea by offline bioassay coupled
doi: 10.1016/j.jpba.2022.115078 with liquid chromatography tandem mass spectrometry.
Food Sci Hum Well. 2022;11(3):627-634.
26. Yang F, Zou Y, Li C, et al. Discovery of potential
hypoglycemic metabolites in Cassiae Semen by coupling doi: 10.1016/j.fshw.2021.12.019
Volume 2 Issue 1 (2025) 69 doi: 10.36922/imo.6010

