Page 74 - IMO-2-1

Innovative Medicines & Omics Flavonoids against glycosidic hydrolase

Funding 6. Han S, Luo Y, Hu Z, D. et al. Targeting gut microbiota in
type 2 diabetes mellitus: Potential roles of dietary flavonoids.
This research was funded by the National Natural Science Food Biosci. 2022;45:101500.
Foundation of China (grant number 32161143021).
doi: 10.1016/j.fbio.2021.101500
Conflict of interest 7. Bui TT, Nguyen HT. Ethanolic extract of Sophora japonica
flower buds alleviates cognitive deficits induced by scopolamine
The authors declare that they have no competing interests.
in mice. Oriental Pharm Exp M. 2017;17(4):337-344.
Author contributions doi: 10.1007/s13596-017-0286-6
Conceptualization: Yunfeng Ma 8. Li J, Gong Y, Li J, et al. In vitro xanthine oxidase inhibitory
Formal analysis: Jiayan Xiong, Jinlin Li, Chaoyang Zhang properties of Flos Sophorae Immaturus and potential
Investigation: Yunfeng Ma mechanisms. Food Biosci. 2022;47:101711.
Methodology: Jinting Sun, Ranying Zhang, Jiayan Xiong doi: 10.1016/j.fbio.2022.101711
Writing–original draft: Ranying Zhang 9. Liu C, Ma C, Lu J, et al. A rapid method and mechanism to
Writing–review & editing: Yunfeng Ma identify the active compounds in Malus micromalus Makino
fruit with spectrum-effect relationship, components knock-
Ethics approval and consent to participate out and molecular docking technology. Food Chem Toxicol.
Not applicable. 2021;150:112086.
doi: 10.1016/j.fct.2021.112086
Consent for publication
10. Li W, Zhang Y, Shi S, et al. Spectrum-effect relationship
Not applicable. of antioxidant and tyrosinase activity with Malus pumila
flowers by UPLC-MS/MS and component knock-out
Availability of data method. Food Chem Toxicol. 2019;133:110754.

Data are available from the corresponding author on doi: 10.1016/j.fct.2019.110754
reasonable request.
11. Li F, Fu Y, Yang H, et al. The inhibition mechanism of luteolin
References on peroxidase based on multispectroscopic techniques. Int J
Biol Macromol. 2021;166:1072-1081.
1. Zheng Y, Tian J, Yang W, et al. Inhibition mechanism of doi: 10.1016/j.ijbiomac.2020.10.262
ferulic acid against α-amylase and α-glucosidase. Food
Chem. 2020;317:126346. 12. Fu M, Shen W, Gao W, et al. Essential moieties of myricetins,
quercetins and catechins for binding and inhibitory activity
doi: 10.1016/j.foodchem.2020.126346
against alpha-Glucosidase. Bioorg Chem. 2021;115:105235.
2. Hussain T, Tan B, Murtaza G, et al. Flavonoids and type 2 doi: 10.1016/j.bioorg.2021.105235
diabetes: Evidence of efficacy in clinical and animal studies
and delivery strategies to enhance their therapeutic efficacy. 13. Kazeem MI, Davies TC. Anti-diabetic functional foods as
Pharmacol Res. 2020;152:104629. sources of insulin secreting, insulin sensitizing and insulin
mimetic agents. J Funct Foods. 2016;20:122-138.
doi: 10.1016/j.phrs.2020.104629
doi: 10.1016/j.jff.2015.10.013
3. Xu X, Wang P, Wang B, et al. Glucose absorption regulation
and mechanism of the compounds in Lilium lancifolium 14. Sansenya S, Payaka A, Mansalai P. Biological activity and
Thunb on Caco-2 cells. Food Chem Toxicol. 2021;149:112010. inhibition potential against α-glucosidase and α-amylase
of 2,4-di-tert-butylphenol from bamboo shoot extract by in
doi: 10.1016/j.fct.2021.112010
vitro and in silico studies. Process Biochem. 2023;126:15-22.
4. Cui L, Wang J, Wang M, et al. Chemical composition and 15. Xiao Y, Shan X, Wang H, et al. Spectrum-effect relationship
glucose uptake effect on 3T3-L1 adipocytes of Ligustrum between HPLC fingerprint and antioxidant of “San-Bai
lucidum Ait. Flowers. Food Sci Hum Well. 2020;9(2):124-129.
Decoction” extracts. J Chromatogr B Analyt Technol Biomed
doi: 10.1016/j.fshw.2020.02.002 Life Sci. 2022;1208:123380.
5. Sabiu S, O’Neill FH, Ashafa AOT. Kinetics of α-amylase and doi: 10.1016/j.jchromb.2022.123380
α-glucosidase inhibitory potential of Zea mays Linnaeus 16. Ma TC, Sun Y, Guo LN, et al. Screening potential
(Poaceae), Stigma maydis aqueous extract: An in vitro α-glucosidase inhibitors from Anemarrhena asphodeloides
assessment. J Ethnopharmacol. 2016;183:1-8.
using response surface methodology coupled with grey
doi: 10.1016/j.jep.2016.02.024 relational analysis. Chin Herb Med. 2019;11(1):60-69.

Volume 2 Issue 1 (2025) 68 doi: 10.36922/imo.6010