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16 INNOSC Theranostics and Pharmacological Sciences, 2023, Vol. 6, No. 1 Dudhat
impose as much socially disruptive restrictions on patients [15-17]. The COVID-19 global pandemic
patients [4,5]. Our goals were to investigate the had a wide-ranging impact on health care services,
causes of pulmonary fibrosis and conceptualize the interfering with the flow of patients to medical
cell differentiation agent (CDA) formulations that facilities as usual, taxing, and overwhelming
can be used as efficient treatments for the disease. the system’s resources, and forcing the adoption
The repair of lung damage brought on by of additional protective measures and social
COVID-19 infection is crucial to restoring lung segregation with increased telehealth and remote
function. However, the healing process is not treatments use.
going as it should be as evident in the formation
of pulmonary fibrosis [6,7]. Another outcome of 2. Viewpoints and conversations
improper wound healing is the development of The concept of chemotherapy surveillance was
cancer [8]. COVID-19 infection must, therefore, introduced as a built-in protection against cancer.
have a significant impact on cancer, and vice Later, it was altered as a natural system to guarantee
versa. Chemosurveillance is a built-in process that optimal wound healing as the main goal of
controls how well wounds heal [8-10]. A careful preventing the development of diseases as a result
investigation of how COVID-19 infection affects of improper wound healing. Cancer, dementia,
cancer patients is conducted. and tissue fibrosis are some of the illnesses linked
A reported risk factor for the emergence of to poor wound healing [18,19]. The idea behind
severe events was receiving cancer therapy within chemosurveillance was inspired by the discovery
14 days of receiving a COVID-19 diagnosis [11]. that while cancer patients frequently displayed
Septic shock, acute myocardial infarction, and deficiencies of these metabolites due to excessive
acute respiratory distress syndrome are a few of urinary excretion, healthy individuals were able
the reported serious complications in the study to maintain a steady level of metabolites active as
group. Millions of people worldwide are affected differentiation inducers (DIs) and differentiation
by the deadly illness of cancer. Patients with cancer helper inducers (DHIs) [20]. DIs are compounds that
must attend medical institutions more frequently can remove telomerase from aberrant methylation
than individuals with other diseases because of enzymes (MEs), while DHIs are ME inhibitors [21].
the nature of the disease and its treatment [12]. Methionine adenosyltransferase (MAT)-
Multidisciplinary teams must be fully involved in methyltransferase (MT)-S-adenosylhomocysteine
the treatment of cancer patients at all stages of the hydrolases (SAHH) are the building blocks of
disease, from diagnosis to survivorship or end-of- MEs. Since the hypomethylation of nucleic acids
life care. Patients need numerous hospital visits is a crucial mechanism for achieving terminal
over the course of the disease for evaluation by differentiation, the connection of telomerase with
various clinicians, as well as numerous imaging or MEs renders MEs to be highly persistent and
laboratory tests for diagnosis, staging, or monitoring active [22]. Normal stem cells, also known as
the effects of treatment, in addition to various types progenitor stem cells (PSCs), produce telomerase,
of surgeries and interventions [13]. which causes MEs to become aberrant cancer cells
Patients with cancer require assistance from (CCs). The cells responsible for wound healing are
a wide range of professionals in addition to the PSCs, which require DIs and DHIs to promote
medical professionals, including social workers, terminal differentiation for effective wound
psychologists, educators, and other support healing [23]. CDA is the moniker given to the
services. Patients who have been diagnosed with concoction of DIs and DHIs. CDAs are metabolites
cancer require ongoing care and support both that aid in wound healing and are actively involved
during and after treatment [14]. Because any in chemo-surveillance. Depending on the extent
unjustified divergence from the well-established of cancer, patients have varying degrees of CDA
standards may result in fragmented and subpar care insufficiency [24].
and a worse patient outcome, these services should Low molecular weight metabolites include
be operating in harmony and a timely manner DIs and DHIs. Major DIs include acidic peptides
with strong commitment and compliance from the and organic acids. Uroerythrin and pregnenolone

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