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12 INNOSC Theranostics and Pharmacological Sciences, 2023, Vol. 6, No. 1 Vishwakarma, et al.
treatment of P. pulmonarius with acarbose mushrooms are becoming increasingly known
prevented a decrease in the body weight of the for its potential in treating diseases. In diabetes,
diabetic mice in a very effective manner. The ability some herbal alternatives are proven to provide
to prevent body weight loss seems to be due to its symptomatic relief and assist in the prevention
ability to suppress hyperglycemia. STZ-induced of secondary complications of the disease.
diabetes was characterized by a severe loss in body Alternative therapies for diabetes treatment are
weight and this reduction in body weight is due to needed because of inability of current therapies to
the loss or degradation of structural proteins since contribute to normoglycemia and prevent diabetic
structural proteins are known to contribute to the complications. Despite of their effectiveness in
body weight. The previous reports showed that reducing hyperglycemia, the use of these drugs
protein synthesis is decreased in all tissues due is associated with non-desirable side effects.
to decreased production of ATP and absolute or Mushrooms are exemplary sources of natural
relative deficiency of insulin [34]. medicines with antidiabetic potential. They serve
Diabetes mellitus has been found to be as an ideal choice for diabetic patients due to their
associated with neutrophilic dysfunction and high content of fiber and protein along with low
lymphocyte function impairments. Leukocyte fat content. P. ostreatus has immense potential and
such as neutrophils, monocytes, and eosinophils can be developed as effective and safe antidiabetic
as well as hematocrit was found to be significantly drug. However, a further study is needed to identify
increased in the diabetic animals when compared to the active fractions responsible for antidiabetic
the normal animals, and this condition on treatment activity and to clarify the mechanism of the effect.
with the infusion of the mushroom was significantly
reverted to the near normal level [35]. STZ-induced Acknowledgments
diabetic rats were treated with AEPO, and results
obtained were compared with normal rats, diabetic The authors wish to thank the head of Department of
rats (without treatment) and metformin-treated Botany and Zoology head, Gorakhpur University,
rats. The results from the present study showed Gorakhpur for providing laboratory facilities.
the significant changes in biochemical parameters Funding
during the experimentally inducted diabetes. Blood
glucose, hemoglobin, total WBC, leukocyte count, The research work has not received any financial
lipid profile, creatinine level, serum uric acid, serum support.
urea, and serum BUN levels were determined
in control and aqueous extract- and metformin- Conflict of interest
treated rats. The present study clearly showed that
P. ostreatus lowers blood lipid levels by reducing The authors declare no conflict of interest related to
the levels of total serum cholesterol, VLDL, LDL this publication.
and serum triglyceride, and it increased serum Author contributions
HDL level, in keeping with work done by Agrawal
et al. [31] on oyster mushroom (Pleurotus spp). Conceptualization: Pratima Vishwakarma
According to Yang et al. [36], Collybia confluens Formal analysis: Pratima Vishwakarma, Nijendra
mycelial powder (CCMP) lowered the plasma total Nath Tripathi
cholesterol, triglyceride, and LDL by 22.9%, 19.9%, Investigation: Pratima Vishwakarma, Veena B.
Kushwaha
and 37.3%, respectively. In summary, the study Writing – original draft: Pratima Vishwakarma,
presented the potential beneficial effects of an AEPO Siddhartha Kumar Mishra
that were exerted through an antihyperglycemic Writing – review & editing: Siddhartha Kumar Mishra
mechanism in diabetic animal model.
Ethics approval and consent to participate
5. Conclusions
The protocols for these experiments were approved
While many plants that are known to be able to by the Animal Ethical Committee of the Institute
treat ailments in humans are emerging nowadays, (IAEC/DDU/2021-22).
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