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INNOSC Theranostics and Pharmacological Sciences 2023 Vol. 6 (No. 1) pp: 1-14

INNOSC Theranostics and Pharmacological Sciences

Journal homepage: https://accscience.com/journal/ITPS

RESEARCH ARTICLE
Orally Administered Aqueous Extract of Pleurotus ostreatus

Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Rats

Pratima Vishwakarma *, Nijendra Nath Tripathi , Veena B. Kushwaha , Siddhartha Kumar Mishra *
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1
3
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1 Bacteriology and Natural Pesticide Laboratory, Department of Botany, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur,
India
2 Department of Zoology, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur, India
3 Department of Biochemistry, University of Lucknow, Lucknow, India
*Corresponding Authors: Pratima Vishwakarma, Email: pratima.vishwakarma12@gmail.com; Siddhartha Kumar Mishra,
Email: siddharthakm@yahoo.com

Received: November 22, 2022; Accepted: March 15, 2023; Published: March 28, 2023 DOI: 10.36922/itps.273
Copyright: Author(s). This is an open-access article distributed under the terms of the Attribution Non-Commercial 4.0 International
4.0 (CC BY-NC 4.0), which permits all non-commercial use, distribution, and reproduction in any medium, provided the original
work is properly cited.

Abstract:

Pleurotus ostreatus (Jacq.) P. Kumm. (Family: Pleurotaceae), commonly known as oyster mushroom, has been widely used to treat
various ailments from simple headache to serious ones like diabetes. The mushroom has been shown to exert anti-inflammatory
and antioxidant activities. In the present study, aqueous extract of P. ostreatus (AEPO) was examined for its antidiabetic activity
in streptozotocin (STZ)-induced diabetic rats. STZ was administered to rats at 50 mg/kg body weight (i.p.), AEPO was orally
administered at 100 and 200 mg/kg body weight, and metformin (500 mg/kg) was administered as positive control. The hypoglycemic
effects of the AEPO were analyzed by assessing the blood glucose levels (oral glucose tolerance test, acute and postprandial
antihyperglycemic activity), lipid parameters, and other hematological studies in comparison to standard drug (metformin). Results
showed that AEPO caused a 26% reduction in blood glucose during fasting while 45% reduction in blood glucose during postprandial
antihyperglycemic test in STZ-diabetic rats. It also helped in the normalizations of various complications associated with diabetes
mellitus in rats. Observations from the current experiments indicate that P. ostreatus help in reduction of blood glucose level, thus
confirming its antidiabetic activity in STZ-induced diabetes in rats. This study further advocates that supplementation of edible
mushroom P. ostreatus could be a preventive approach in diabetes as well as in obesity management.

Keywords: Antidiabetic, Pleurotus ostreatus, Streptozotocin, Metformin

1. Introduction diabetes, which is projected to rise to 643 million
by 2030 and 783 million by 2045. An estimated
Diabetes mellitus is known since ages as it has been 6.7 million deaths due to diabetes were reported
mentioned in Ayurveda by Sushruta [1]. Diabetes in 2021. The incidences of diabetes are higher
mellitus is a chronic metabolic disease characterized (3 in 4 adults) in low- and middle-income countries.
by elevated plasma glucose concentration in fasting Diabetes is characterized as a state of imbalance
or postprandial state, or insulin resistance [2]. toward the factors that generate reactive oxygen
The World Health Organization and International radicals such as superoxide or hydroxyl radicals,
Diabetes Federation reported an estimate of and the level of antioxidant enzymes such as
10.5% (536.6 million people) global prevalence of superoxide dismutases, catalase, and glutathione

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