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INNOSC Theranostics and
Pharmacological Sciences BDNF-AS biomarker in multiple sclerosis

RNAs in glioblastoma: Regulatory mechanisms and clinical et al. BDNF and Tau as biomarkers of severity in multiple
potentials. Int J Genomics. 2018;2018:2895958. sclerosis. Biomark Med. 2018;12(7):717-726.
doi: 10.1155/2018/2895958 doi: 10.2217/bmm-2017-0374
15. Bridges MC, Daulagala AC, Kourtidis A. LNCcation: 26. Tongiorgi E, Sartori A, Baj G, et al. Altered serum content
lncRNA localization and function. J Cell Biol. of brain-derived neurotrophic factor isoforms in multiple
2021;220(2):e202009045. sclerosis. J Neurol Sci. 2012;320(1-2):161-165.
doi: 10.1083/jcb.202009045 doi: 10.1016/j.jns.2012.07.016
16. Lein ES, Hawrylycz MJ, Ao N, et al. Genome-wide atlas 27. Naegelin Y, Saeuberli K, Schaedelin S, et al. Levels of brain-
of gene expression in the adult mouse brain. Nature. derived neurotrophic factor in patients with multiple
2007;445(7124):168-176. sclerosis. Ann Clin Transl Neurol. 2020;7(11):2251-2261.
doi: 10.1038/nature05453 doi: 10.1002/acn3.51215
17. Mercer TR, Dinger ME, Sunkin SM, Mehler MF, Mattick JS. 28. Azoulay D, Vachapova V, Shihman B, Miler A, Karni A.
Specific expression of long noncoding RNAs in the mouse Lower brain-derived neurotrophic factor in serum of
brain. Proc Natl Acad Sci. 2008;105(2):716-721. relapsing remitting MS: Reversal by glatiramer acetate.
doi: 10.1073/pnas.0706729105 J Neuroimmunol. 2005;167(1-2):215-218.
18. Cuevas-Diaz Duran R, Wei H, Kim DH, Wu JQ. Invited doi: 10.1016/j.jneuroim.2005.07.001
review: Long non-coding RNAs: Important regulators in the 29. Hamamcioglu K, Reder AT. Interferon-β regulates cytokines
development, function and disorders of the central nervous and BDNF: Greater effect in relapsing than in progressive
system. Neuropathol Appl Neurobiol. 2019;45(6):538-556. multiple sclerosis. Mult Scler. 2007;13(4):459-470.
doi: 10.1111/nan.12541 doi: 10.1177/1352458506069672
19. Ghafouri-Fard S, Khoshbakht T, Taheri M, Ghanbari M. A 30. Karimi N, Ashourizadeh H, Akbarzadeh Pasha B, et al.
concise review on the role of BDNF-AS in human disorders. Blood levels of brain-derived neurotrophic factor (BDNF)
Biomed Pharmacother. 2021;142:112051. in people with multiple sclerosis (MS): A systematic review
doi: 10.1016/j.biopha.2021.112051 and meta-analysis. Mult Scler Relat Disord. 2022;65:103984.
doi: 10.1016/j.msard.2022.103984
20. Shkundin A, Halaris A. Associations of BDNF/BDNF-AS
SNPs with depression, schizophrenia, and bipolar disorder. 31. Gharzi V, Ganji M, Sayad A, Mazdeh M, Arsang-Jang S,
J Pers Med. 2023;13(9):1395. Taheri M. Expression analysis of BDNF gene and BDNF-As
long noncoding RNA in whole blood samples of multiple
doi: 10.3390/jpm13091395 sclerosis patients: Not always a negative correlation between
21. Zheng X, Lin C, Li Y, Ye J, Zhou J, Guo P. Long noncoding them. Iran J Allergy Asthma Immunol. 2018;17(6):548-556.
RNA BDNF-AS regulates ketamine-induced neurotoxicity 32. World Medical Association. World medical association
in neural stem cell derived neurons. Biomed Pharmacother. declaration of Helsinki: Ethical principles for medical research
2016;82:722-728. involving human subjects. JAMA. 2013;310(20):2191-2194.
doi: 10.1016/j.biopha.2016.05.050 doi: 10.1001/jama.2013.281053
22. Qiao LX, Zhao RB, Wu MF, Zhu LH, Xia ZK. Silencing of 33. Polman CH, Reingold SC, Banwell B, et al. Diagnostic
long non-coding antisense RNA brain-derived neurotrophic criteria for multiple sclerosis: 2010 revisions to the
factor attenuates hypoxia/ischemia-induced neonatal brain McDonald criteria. Ann Neurol. 2011;69(2):292-302.
injury. Int J Mol Med. 2020;46(2):653-662.
doi: 10.1002/ana.22366
doi: 10.3892/ijmm.2020.4625
34. Kurtzke JF. Rating neurologic impairment in multiple
23. Ksiazek-Winiarek DJ, Szpakowski P, Glabinski A. Neural sclerosis: An expanded disability status scale (EDSS).
plasticity in multiple sclerosis: The functional and molecular Neurology. 1983;33(11):1444-1452.
background. Neural Plast. 2015;2015:307175.
doi: 10.1212/wnl.33.11.1444
doi: 10.1155/2015/307175
35. Zweig MH, Campbell G. Receiver-operating characteristic
24. Nociti V. What is the role of brain derived neurotrophic factor (ROC) plots: A fundamental evaluation tool in clinical
in multiple sclerosis neuroinflammation? Neuroimmunol medicine. Clin Chem. 1993;39(4):561-577.
Neuroinflamm. 2020;7(3):291-299.
36. Pisani A, Paciello F, Del Vecchio V, et al. The role of BDNF
doi: 10.20517/2347-8659.2020.25
as a biomarker in cognitive and sensory neurodegeneration.
25. Islas-Hernandez A, Aguilar-Talamantes HS, Bertado-Cortes B, J Pers Med. 2023;13(4):652.

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