Page 99 - ITPS-8-3

INNOSC Theranostics

and Pharmacological Sciences

MINI-REVIEW
Early identification of cardiovascular health

risks in pre-eclampsia: A biomarker-centric
perspective

Abhishek Gupta * , Komal Shah 1 , and Vani Gupta 2
1,2
1 Department of Public Health, Indian Institute of Public Health, Gandhinagar, Gujarat, India
2 Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India

Abstract
Pre-eclampsia is a complicated hypertensive pregnancy condition that has a
major effect on the health of both the mother and the fetus and puts the affected
women at risk for long-term cardiovascular (CV) problems. Despite advances in
understanding its etiology, early detection of pre-eclampsia and its associated CV
risks remains challenging. This mini-review emphasizes the critical role of biomarkers
and advanced diagnostic techniques in addressing this gap. Emerging biomarkers,
including angiogenic factors (soluble fms-like tyrosine kinase-1/placental growth
factor ratio), metabolic and lipidomics markers, inflammatory cytokines, and
exosomal components, provide promising pathways for early identification and risk
stratification. Diagnostic techniques can be further improved by classifying these
*Corresponding author: biomarkers according to their capacity to predict long-term CV risks. Technological
Abhishek Gupta advancements, such as omics platforms, molecular imaging, wearable health
(abhikgmu@gmail.com) devices, and artificial intelligence (AI) and machine learning, further improve real-
Citation: Gupta A, Shah K, time detection and personalized management of pre-eclampsia. By focusing on
Gupta V. Early identification of biomarker-centric predictors of CV risks, this review highlights the integration of
cardiovascular health risks in multi-biomarker panels and AI-driven algorithms to optimize risk prediction. The
pre-eclampsia: A biomarker-centric
perspective. INNOSC Theranostics transition from association to action is explored, with an emphasis on translating
and Pharmacological Sciences. knowledge into effective prevention strategies and improved risk assessment
2025;8(3):93-100. protocols. Structured postpartum follow-up is advocated to monitor and mitigate
doi: 10.36922/itps.7839
long-term CV risks in pre-eclamptic women. Practical applications, including
Received: December 17, 2024 targeted interventions and personalized risk management strategies, are discussed.
Revised: January 23, 2025 By bridging cutting-edge research and clinical practice, this review aims to enhance
maternal health outcomes and advance preventative measures for CV diseases in
Accepted: February 24, 2025
women with a history of pre-eclampsia.
Published online: March 6, 2025
Copyright: © 2025 Author(s). Keywords: Pre-eclampsia; Hypertension; Pregnancy; Cardiovascular disease; Biomarkers;
This is an Open-Access article
distributed under the terms of the Health risk
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited. 1. Introduction
Publisher’s Note: AccScience Pre-eclampsia is a complex and potentially fatal pregnancy hypertensive condition that
Publishing remains neutral with manifests as proteinuria and new-onset hypertension after 20 weeks of pregnancy. It
1-4
regard to jurisdictional claims in
published maps and institutional affects 5 – 15% of pregnancies worldwide and is a leading cause of maternal and perinatal
5,6
affiliations. morbidity and mortality. This condition increases the risk of long-term cardiovascular
Volume 8 Issue 3 (2025) 93 doi: 10.36922/itps.7839