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Gonda et al. | Journal of Clinical and Translational Research 2024; 10(1): 33-51   45
        Table 1. (Continued)
        Blood biomarkers                         Admission      Day 5      P‑value 1               Day 14     P‑value 2
         PT-INR
           Molnupiravir                           1.1±0.4      1.4±0.1      <0.05                  1.1±0.1      n.s.
           Molnupiravir + CAM                     1.1±0.3      1.2±0.1       n.s.                  1.1±0.1      n.s.
           Uninfected                             1.1±0.4      1.2±0.6       n.s.                  1.1±0.2      n.s.
           P-value*                                 n.s.        <0.05                 P-value**     n.s.
        Cardiac biomarkers
         CPK (IU/L)
           Molnupiravir                           40±22.2     94.3±103.5    <0.05                 50.6±44.4     n.s.
           Molnupiravir + CAM                     49.0±30.5   76.25±88.2     n.s.                 41.1±22.7     n.s.
           Uninfected                             40.3±34.0    33.3±13.2     n.s.                 30.5±13.5     n.s.
           P-value*                                 n.s.         n.s.                 P-value**     n.s.
         BNP (pg/ml)
           Molnupiravir                          121.3±142.3  158.4±128.2    n.s.                 86.3±92.6     n.s.
           Molnupiravir + CAM                    113.4±228.6  147.0±78.3     n.s.                 86.8±153.9    n.s.
           Uninfected                            108.3±139.6  105.7±132.8    n.s.                 108.4±96.1    n.s.
           P-value*                                 n.s.         n.s.                 P-value**     n.s.
        Abbreviations:  CAM:  Clarithromycin,  n.s.:  No  significant  difference,  LDH:  Lactate  dehydrogenase,  WBC:  White  blood  cells,  Hb:  Hemoglobin,  PLT:  Platelet,  CRP:  C-reacted  protein,
        NLR: Neutron–lymphocyte ratio, FDP: Fibrin degradation product, PT-INR: Prothrombin time-International Normalized Ratio, CPK: Creatinine phosphor kinase, BNP: Brain natriuretic peptide.
        P-value*: Molnupiravir alone group and molnupiravir + CAM group on the 5  day.
                                                    th
        P-value**: Molnupiravir alone group and molnupiravir + CAM group on the 14  day.
                                                     th
        P-value : The time of admission and on the 5  day from the start of admission.
             1
                                  th
        P-value : The time of admission and on the 14  day from the start of admission.
             2
                                  th
        Notes: The cutoff values were as follows: LDH (115 – 245 IU/L), total cholesterol (130 – 219 mg/dl), triglyceride (30 – 149 mg/dl), uric acid (2.5 – 7.0 mg/dl), creatinine (0.47 – 0.79 mg/dl),
        potassium (3.4 – 5.0 mEq/L), WBC (35 – 90×10 /μl), Hb (11.5 – 15.2 g/dl), PLT (12 – 40×10 /μl), CRP (<0.3 mg/dl), neutrophils (28 – 68%), lymphocytes (18 – 51%), NLR (0.55 – 3.78),
                                                              4
                                    2
        fibrinogen (150 – 400 mg/dl), FDP (<4 μg/ml), D-dimer (<1.0 μg/ML), PT-INR (0.8 – 1.2), CPK (45 – 163 IU/L), BNP (<18.4 pg/ml)





































                                                  DOI: https://doi.org/10.36922/jctr.00075
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