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Gonda et al. | Journal of Clinical and Translational Research 2024; 10(1): 33-51 49

Table 3c. Baseline characteristics of COVID-19 patients receiving
molnupiravir alone or uninfected patients
Characteristics Molnupiravir Uninfected P‑value
(n=37) (n=28)
Female gender 23 (62.2%) 12 (42.8%) n.s.
Age (years) 76 (67 – 100) 76 (69 – 100) n.s.
Male gender 14 (37.8%) 16 (57.1%) n.s.
Age (years) 73 (64 – 96) 73 (74 – 100) n.s.
Baseline symptoms
Fever 0 (0%) 0 (0%) n.s.
Cough and sputa 0 (0%) 0 (0%) n.s.
Fatigue 21 (56.7%) 0 (0%) <0.05
Shortness of breath 0 (0%) 0 (0%) n.s.
Chest tightness 0 (0%) 0 (0%) n.s.
Dyspnea (93% < SpO < 96%) 0 (0%) 0 (0%) n.s.
2
Nausea 19 (51.3%) 0 (0%) <0.05
Vomit 11 (29.7%) 0 (0%) <0.05
Headache 4 (10.8%) 0 (0%) <0.05
Chills 0 (0%) 0 (0%) n.s.
Diarrhea 2 (5.4%) 0 (0%) <0.05
Hair removal 1 (2.7%) 0 (0%) <0.05
Cingulum 1 (2.7%) 0 (0%) <0.05
Skin rash 2 (5.4%) 0 (0%) <0.05
Conjunctiva inflammation 1 (2.7%) 0 (0%) <0.05
Myalgia 0 (0%) 0 (0%) n.s.
Abdominal pain 0 (0%) 0 (0%) n.s.
Blood cough 0 (0%) 0 (0%) n.s.
Charlson index 16 (43.2%) 0 (0%) <0.05
Baseline comorbidity
Cardiovascular disease 1 34 (91.9%) 24 (85.7%) n.s.
Cerebrovascular disease 2 32 (86.5%) 23 (82.1%) n.s.
Respiratory diseases 3 0 (0%) 19 (67.9%) n.s.
Orthopedic disease 4 28 (75.7%) 22 (78.6%) n.s.
Hypertension 26 (70.3%) 21 (65.6%) n.s.
Diabetes mellitus 15 (40.5%) 18 (64.3%) n.s.
Cancer 5 13 (35.1%) 15 (53.6%) n.s.
Chronic renal failure 8 (21.6%) 11 (39.3%) n.s.
Vaccination 35/37 (94.6%) 25/28 (89.3%) n.s.
Within 6 months before admission 33/35 (94.2%) 21/25 (84%) n.s.
1 vaccination 31/33 (93.9%) 19/21 (90.4%) n.s.
2 vaccinations 2/33 (6.1%) 1/21 (4.7%) n.s.
Within 3 months before admission 2/35 (5.7%) 1/25 (4.0%) n.s.
1 vaccination 1/2 (50%) 0/1 (0%) <0.05
2 vaccinations 1/2 (50%) 0/1 (0%) <0.05
Abbreviation: n.s.: No significant difference
1 Heart failure, myocardial infarction, angina pectoris, arrhythmia, dilatation of the
myocarditis, dissecting aneurysm of aorta
2 Cerebral infarction, brain hemorrhage, subarachnoid hemorrhage, cerebral aneurysm
3 Chronic obstructive pulmonary disease, chronic bronchitis, chronic interstitial pneumonia,
bronchial asthma
4 Fracture, prosthesis replacement
5 Esophageal cancer, gastric cancer, pancreatic cancer, liver cancer, cholangiocarcinoma,
colorectal cancer, lung cancer, breast cancer, ovarian cancer, laryngeal cancer, tongue
cancer, meningioma

DOI: https://doi.org/10.36922/jctr.00075