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Wang et al. | Journal of Clinical and Translational Research 2024; 10(2): 159-164   163
        electrical neuromuscular stimulator utilizes lower frequencies and   Consent for Publication
        voltages (≤21 V).
          It  has  been  reported  that  pain  severity  is  correlated  to  the   The  authors have obtained  the  written  and signed informed
        impact on the quality of life of individuals suffering from herpes   consent of the patients for releasing their data in this paper.
        zoster-related pain [24]. Furthermore, the integration of the pulsed   Availability of Data
        microcurrent with standard medication in the experimental group
        resulted in superior pain relief outcomes compared to the control   Data  are  available  from  the  corresponding  author  upon
        group.  This  combined  approach  also  effectively  ameliorated   reasonable request.
        depression and anxiety symptoms in the patients, consistent with
        the findings by Zhang et al. that distinct pulsed radiofrequency   References
        temperatures resulted in notable improvements in pain, depression,   [1]   Liao YL, Yang SM, Chen P, Li DS, Huang JB, Sun WP,
        and anxiety among postherpetic neuralgia patients [25].       et al. Investigation of Anxiety and Depression Status and
          Immunosuppression,  particularly  prevalent  among  the  elderly,   Correlation Analysis of Cortisol Hormone Level Changes
        stands out as a pivotal factor in the onset of herpes zoster. Beyond   in Patients with Herpes Zoster Neuralgia. Chi J Pain Med
        the age of 50, there is a gradual waning of varicella zoster virus-  2020;26:137-40.
        specific cell-mediated immunity, leading to an increased occurrence   [2]   Expert  Consensus  Working  Group  on  Herpes  Zoster,
        of herpes zoster. The prevalence of herpes zoster in China closely
        mirrors that of other global regions, with an incidence rate among   Dermatologists  Branch,  Chinese  Physicians Association.
        the elderly aged 50 and above of 2.9–5.8 cases per 1000 people [26].   Chinese  Expert  Consensus  on  Herpes  Zoster.  Chin  J
        Notably, the present study featured a relatively small sample size   Dermatol 2018;51:403-8.
        with a broad age spectrum, i.e., the mean age of the experimental and      doi: 10.3760/cma.j.issn.0412-4030.2018.06.001
        control groups was 52.47 ± 3.28 and 55.63 ± 4.96 years, respectively.   [3]   Wang L, Fan Z, Qin J, Xu R, Wang D. Research Progress
        The experimental group, characterized by a comparatively younger   of Varicella-Zoster Virus (VZV) Treatment. Chin J Infect
        average age, exhibited a significantly shorter recovery duration than   Dis 2017;35:571-3.
        the control group, suggesting a potential synergistic effect of age      doi: 10.3760/cma.j.issn.1000-6680.2017.09.018
        and pulsed microcurrent electrical therapy.             [4]   Kim K, Jo D, Kim E. Pulsed Radiofrequency to the Dorsal
        5. Conclusion                                                 Root  Ganglion  in Acute  Herpes  Zoster  and  Postherpetic
                                                                      Neuralgia. Pain Physician 2017;20:E411-8.
          Pulsed microcurrent electrical therapy demonstrated remarkable   doi: 10.13359/j.cnki.gzxbtcm.2021.07.006
        effectiveness in reducing herpes zoster-related pain. Consequently,   [5]   Lin  CS,  Lin  YC,  Lao  HC,  Chen  CC.  Interventional
        the intervention also significantly alleviated herpes-zoster-induced
        depression and anxiety in patients. Taken together, the widespread   Treatments  for  Postherpetic  Neuralgia:  A  Systematic
        implementation and utilization of pulsed microcurrent electrical   Review. Pain Physician 2019;22:209-28.
        therapy in clinical settings hold significant promise as a therapeutic   [6]   Wan C, Dong DS, Song T. High-Voltage, Long-Duration
        option for herpes zoster. However, further studies are warranted to   Pulsed Radiofrequency on Gasserian Ganglion Improves
        delve into the underlying mechanisms involved in the reduction of   Acute/Subacute  Zoster-Related  Trigeminal  Neuralgia:
        herpes zoster-associated pain.                                A  Randomized,  Double-Blinded,  Controlled  Trial.  Pain
                                                                      Physician 2019;22:361-8.
        Acknowledgments                                         [7]   Guo S, Shen M, Zhang L, Zhao Q, Song C, Jia W, et al.

          None.                                                       The Effect of Interventional Pain Management on Treating
                                                                      Postherpetic Neuralgia. Indian J Dermatol 2019;64:251-60.
        Funding                                                       doi: 10.4103/ijd.IJD_130_18

          This  study  was  funded  by  the  Industrialization  Project  of   [8]   Jia Y, Shen Y, Meng L, Wang T, Luo F. Efficacy, Safety, and
        the  Education  Department  of  Shaanxi  Province  (20JC031)  and   Predictors of Response to Pulsed Radiofrequency Therapy
        the  Science  and Technology  Innovation Team  Project  of  Xi’an   for Acute  Zoster-Related  Trigeminal  Neuralgia  Patients:
        Medical University (2021TD14).                                A  Multicenter  Retrospective  Study.  Pain  Physician
                                                                      2022;25:E523-30.
        Conflicts of Interest
                                                                [9]   National Medical Products Administration. Local Medical
          The authors declare that they have no competing interests.  Devices  (Registration  History  Data):  Shaanxiezhuzhun
                                                                      20182260068. Available from: https://www.nmpa.gov.cn/
        Ethics Approval and Consent to Participate                    datasearch/
          This  study  was  approved  by  the  Human  Research  Ethics   [10]  Aicher B, Peil H, Peil B, Diener HC. Pain Measurement:
        Committee  of  the  First  Affiliated  Hospital  of  Xi’an  Medical   Visual  Analogue  Scale  (VAS)  and  Verbal  Rating  Scale
        University.                                                   (VRS) in Clinical Trials with OTC Analgesics in Headache.
                                                DOI: https://doi.org/10.36922/jctr.23.00121
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