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Wang et al. | Journal of Clinical and Translational Research 2024; 10(2): 159-164 163
electrical neuromuscular stimulator utilizes lower frequencies and Consent for Publication
voltages (≤21 V).
It has been reported that pain severity is correlated to the The authors have obtained the written and signed informed
impact on the quality of life of individuals suffering from herpes consent of the patients for releasing their data in this paper.
zoster-related pain [24]. Furthermore, the integration of the pulsed Availability of Data
microcurrent with standard medication in the experimental group
resulted in superior pain relief outcomes compared to the control Data are available from the corresponding author upon
group. This combined approach also effectively ameliorated reasonable request.
depression and anxiety symptoms in the patients, consistent with
the findings by Zhang et al. that distinct pulsed radiofrequency References
temperatures resulted in notable improvements in pain, depression, [1] Liao YL, Yang SM, Chen P, Li DS, Huang JB, Sun WP,
and anxiety among postherpetic neuralgia patients [25]. et al. Investigation of Anxiety and Depression Status and
Immunosuppression, particularly prevalent among the elderly, Correlation Analysis of Cortisol Hormone Level Changes
stands out as a pivotal factor in the onset of herpes zoster. Beyond in Patients with Herpes Zoster Neuralgia. Chi J Pain Med
the age of 50, there is a gradual waning of varicella zoster virus- 2020;26:137-40.
specific cell-mediated immunity, leading to an increased occurrence [2] Expert Consensus Working Group on Herpes Zoster,
of herpes zoster. The prevalence of herpes zoster in China closely
mirrors that of other global regions, with an incidence rate among Dermatologists Branch, Chinese Physicians Association.
the elderly aged 50 and above of 2.9–5.8 cases per 1000 people [26]. Chinese Expert Consensus on Herpes Zoster. Chin J
Notably, the present study featured a relatively small sample size Dermatol 2018;51:403-8.
with a broad age spectrum, i.e., the mean age of the experimental and doi: 10.3760/cma.j.issn.0412-4030.2018.06.001
control groups was 52.47 ± 3.28 and 55.63 ± 4.96 years, respectively. [3] Wang L, Fan Z, Qin J, Xu R, Wang D. Research Progress
The experimental group, characterized by a comparatively younger of Varicella-Zoster Virus (VZV) Treatment. Chin J Infect
average age, exhibited a significantly shorter recovery duration than Dis 2017;35:571-3.
the control group, suggesting a potential synergistic effect of age doi: 10.3760/cma.j.issn.1000-6680.2017.09.018
and pulsed microcurrent electrical therapy. [4] Kim K, Jo D, Kim E. Pulsed Radiofrequency to the Dorsal
5. Conclusion Root Ganglion in Acute Herpes Zoster and Postherpetic
Neuralgia. Pain Physician 2017;20:E411-8.
Pulsed microcurrent electrical therapy demonstrated remarkable doi: 10.13359/j.cnki.gzxbtcm.2021.07.006
effectiveness in reducing herpes zoster-related pain. Consequently, [5] Lin CS, Lin YC, Lao HC, Chen CC. Interventional
the intervention also significantly alleviated herpes-zoster-induced
depression and anxiety in patients. Taken together, the widespread Treatments for Postherpetic Neuralgia: A Systematic
implementation and utilization of pulsed microcurrent electrical Review. Pain Physician 2019;22:209-28.
therapy in clinical settings hold significant promise as a therapeutic [6] Wan C, Dong DS, Song T. High-Voltage, Long-Duration
option for herpes zoster. However, further studies are warranted to Pulsed Radiofrequency on Gasserian Ganglion Improves
delve into the underlying mechanisms involved in the reduction of Acute/Subacute Zoster-Related Trigeminal Neuralgia:
herpes zoster-associated pain. A Randomized, Double-Blinded, Controlled Trial. Pain
Physician 2019;22:361-8.
Acknowledgments [7] Guo S, Shen M, Zhang L, Zhao Q, Song C, Jia W, et al.
None. The Effect of Interventional Pain Management on Treating
Postherpetic Neuralgia. Indian J Dermatol 2019;64:251-60.
Funding doi: 10.4103/ijd.IJD_130_18
This study was funded by the Industrialization Project of [8] Jia Y, Shen Y, Meng L, Wang T, Luo F. Efficacy, Safety, and
the Education Department of Shaanxi Province (20JC031) and Predictors of Response to Pulsed Radiofrequency Therapy
the Science and Technology Innovation Team Project of Xi’an for Acute Zoster-Related Trigeminal Neuralgia Patients:
Medical University (2021TD14). A Multicenter Retrospective Study. Pain Physician
2022;25:E523-30.
Conflicts of Interest
[9] National Medical Products Administration. Local Medical
The authors declare that they have no competing interests. Devices (Registration History Data): Shaanxiezhuzhun
20182260068. Available from: https://www.nmpa.gov.cn/
Ethics Approval and Consent to Participate datasearch/
This study was approved by the Human Research Ethics [10] Aicher B, Peil H, Peil B, Diener HC. Pain Measurement:
Committee of the First Affiliated Hospital of Xi’an Medical Visual Analogue Scale (VAS) and Verbal Rating Scale
University. (VRS) in Clinical Trials with OTC Analgesics in Headache.
DOI: https://doi.org/10.36922/jctr.23.00121

