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Journal of Clinical and Translational Research 2024; 10(4): 256-262




                                       Journal of Clinical and Translational Research

                                              Journal homepage: http://www.jctres.com/en/home


        ORIGINAL ARTICLE

        Nephroprotective and anti-inflammatory effects of resveratrol topical

        ointment in albino rats following full-thickness cutaneous burn wound



        Daniel Thomas Yoksa , Yusuf Abba *, Bala Usman Shamaki 2
                           1
                                       1
        1 Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno, Nigeria, Department of
                                                                                                  2
        Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno, Nigeria
        ARTICLE INFO                       ABSTRACT

        Article history:                   Background: Recent studies on resveratrol (RSV)  have generated great interest, owing to its
        Received: May 22, 2024             pleiotropic, health-promoting properties that have been documented not only in animals but also
        Accepted: August 13, 2024          in humans to exhibit anti-neoplastic and alleviate oxidative stress and inflammation, anti-diabetic,
        Published Online: August 29, 2024  protective role in cardiac diseases, and anti-ulcerative properties, among others.
                                           Aims: This study is aimed at evaluating the effects of topical RSV ointment on hematology, serum
        Keywords:                          biochemistry,  and  serum  vascular  endothelial  growth  factor  (VEGF),  following  full-thickness
        Resveratrol                        cutaneous burn wound (BW).
        Burn wound                         Methods: Four groups of 15 rats were arranged in groups A (negative control), B (positive drug
        Anti-inflammatory                  control; BW + 1% silver sulphadiazine [SSD] cream), C (experimental group; BW + 5% RSV
        Liver function                     topical application), and D (positive wound control; BW with no topical application of ointment).
        Nephroprotective                   The dorsum was shaved using a clipper, and 23.5 mm of BW was inflicted in groups B–D. Rats from
                                           groups B and C were treated twice daily for 21 days. Five rats from each group were anesthetized
        *Corresponding author:             on days 5, 8, and 21, and blood samples were collected post-wounding (PW).
        Yusuf Abba                         Results:  A  statistically  significant  reduction  in  neutrophil  and  monocyte  counts  in  the
        Department of Veterinary Pathology, Faculty   RSV-treated group was recorded (P < 0.05). Increased aspartate aminotransferase (AST), alanine
        of Veterinary Medicine, University of   aminotransferase (ALT), and alkaline phosphatase (ALP) activities on day 5 were due to acute
        Maiduguri, Maiduguri, Borno, Nigeria  hepatic injury associated with burns but were normalized on days 8 and 21. Serum levels of urea
        Email: yabbavet06@unimaid.edu.ng   and creatinine were lower in the RSV-treated group than in the SSD-treated group on days 5 and 8
                                           post-treatment (PT). The RSV-treated group had a lower VEGF concentration in comparison to
        © 2024 Author(s). This is an Open-  other groups.
        Access article distributed under the terms   Conclusion: The study demonstrated that RSV suppresses neutrophil and monocyte counts in the
        of the Creative Commons Attribution-  peripheral circulation, thus acting as an anti-inflammatory compound. Similarly, RSV exhibited a
        Noncommercial License, permitting all
        non-commercial use, distribution, and   nephroprotective effect by suppressing creatinine and urea levels. RSV reportedly suppressed the
        reproduction in any medium, provided the   serum activity of VEGF, making it a good antineoplastic agent.
        original work is properly cited.   Relevance for Patients: RSV formulation can be used to enhance BW healing in human patients
                                           through its anti-inflammatory effect. RSV can also ameliorate kidney dysfunction associated with
                                           BW in human patients.



                                           1. Introduction
                                             A wound is defined as an injury to the skin caused by physical, chemical, thermal,
                                           microbial,  or  immunological  factors.  Accidental  exposure  to  chemicals,  wildfires,
                                           irradiation, electricity, or sunburn causes burn wounds (BWs) [1]. Burns are categorized
                                           by skin depth: first-degree burns only involve the superficial epidermis; second-degree
                                           burns involve both the epidermis and dermis; and full-thickness burns involve the three
                                           layers of the skin and the underlying blood vessels and muscles [2]. BWs are a broad
                                           category of cutaneous injuries with different healing outcomes compared to penetrating

                                               DOI: https://doi.org/10.36922/jctr.24.00019
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