Page 58 - JCTR-11-2

Journal of Clinical and

Translational Research

ORIGINAL ARTICLE
Retrospective comparative study of CT-guided

needle localization versus medical glue
localization for preoperative management of

pulmonary nodules

†
†
Zhanyu Xu † , Yihua Huang , Zehao Huang , Huajian Peng, Jun Liu, Xu Feng*,
Nuo Yang* , and Jianji Guo*
Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical
University, Nanning, Guangxi Zhuang Autonomous Region, China

Abstract

Background: Video-assisted thoracoscopic surgery (VATS) is the preferred treatment
† These authors contributed equally for pulmonary nodules, making preoperative localization crucial. Aim: This study
to this work. compared the effectiveness and complications of two computed tomography (CT)-
*Corresponding authors: guided localization methods for pulmonary nodules: localization needle and medical
Jianji Guo glue. Methods: This retrospective study included 86 patients with pulmonary
(guojianji@gxmu.edu.cn) nodules undergoing preoperative localization at the First Affiliated Hospital of
Nuo Yang
(yangnuo@gxmu.edu.cn) Guangxi Medical University (July 2023 – April 2024). The patients were divided
Xu Feng into two groups: the localization needle group (n=64) and the medical glue group
(fengxu@sr.gxmu.edu.cn) (n=22). Clinical data, including baseline characteristics, localization-related data,
Citation: Xu Z, Huang Y, Huang Z, complications, and surgical outcomes, were collected and analyzed, and subgroup
et al. Retrospective comparative analyses were done to identify risk factors for pneumothorax and pulmonary
study of CT-guided needle
localization versus medical glue hemorrhage. Results: Both methods achieved a 100% localization success rate, with
localization for preoperative all nodules successfully resected. The needle group had longer localization time
management of pulmonary nodule. (17.19 vs. 15.36 min, p<0.05) and higher pneumothorax incidence (23.4% vs. 4.5%,
J Clin Transl Res. 2025;11(2):52-61.
doi: 10.36922/JCTR025070007 p<0.05). The needle group also had a lower cough incidence (1.6% vs. 22.7%, p<0.05)
but higher pain scores (2.89 vs. 2.36, p<0.05). No significant differences were observed
Received: February 14, 2025 in intrapulmonary hemorrhage, operative time, surgical approach, or postoperative
Revised: February 28, 2025 pathology (p>0.05) between the two groups. However, subgroup analysis revealed
Accepted: March 12, 2025 significant differences in puncture times, localization methods, nodule size, lung
history, and puncture depth related to pneumothorax and hemorrhage (p<0.05).
Published online: March 27, 2025 Conclusion: Both CT-guided localization methods are safe and effective for VATS.
Copyright: © 2025 Author(s). The number of punctures is a key risk factor for complications such as pneumothorax
This is an open-access article and intrapulmonary hemorrhage, emphasizing the importance of careful planning
distributed under the terms
of the Creative Commons and technique during localization. Relevance for patients: Identifying the most
AttributionNonCommercial 4.0 effective localization methods for pulmonary nodules ensures a higher success
International (CC BY-NC 4.0), which rate in surgeries, with fewer complications, ultimately leading to better patient
permits all non-commercial use,
distribution, and reproduction in any outcomes and faster recovery. Proper preoperative localization helps reduce the
medium, provided the original work risk of adverse events like pneumothorax, ensuring safer procedures and improved
is properly cited. overall care for patients.
Publisher’s Note: AccScience
Publishing remains neutral with
regard to jurisdictional claims in Keywords: CT-guided localization; Pulmonary nodules; Needle localization; Medical glue;
published maps and institutional Video-assisted thoracoscopic surgery
affiliations.

Volume 11 Issue 2 (2025) 52 doi: 10.36922/JCTR025070007