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Microbes & Immunity RANTES/CCL5 and ezrin peptide RepG3 for long COVID

Figure 8. The CFTR+EBP50+PKC inflammation switch. On: Active protein complex of CFTR+EBP50+PKC and TIRAP mediates proinflammatory
signaling. Spike triggers TLR4, TIRAP, and the CFTR+EBP50+PKC multi-protein complex to activate p38 MAPK, leading to IKK activation,
phosphorylation of IκB, and dissociation of the p65+IkB+p50 multi-protein complex, leading to NF-κB proinflammatory cytokine expression. Off:
Activated ezrin breaks the connection between EPB50 and PKC, inhibiting inflammatory signaling.

activity and enhance anti-body titers in patients, acting as ezrin peptides have been shown to stimulate anti-
adjuvants during hepatitis B vaccination. 18 inflammatory IL-10 in PHA-stimulated human PBMC.
RANTES/CCL5 and ezrin peptides both increased RANTES/CCL5 and ezrin peptides both activate the
anti-inflammatory cytokine IL-10 expression. Ras>Raf>MEK>ERK intra-cellular-signaling pathway.
RANTES/CCL5 has been shown to stimulate anti- In addition, RANTES/CCL5 and ezrin peptides induced
inflammatory IL-10 in rat VCSM cells, while leukocyte migration and homing. RANTES/CCL5 and

Volume 1 Issue 1 (2024) 18 doi: 10.36922/mi.2474