Page 30 - MI-1-1
P. 30
Microbes & Immunity RANTES/CCL5 and ezrin peptide RepG3 for long COVID
doi: 10.4049/jimmunol.164.10.5352 motif. Mol Cell Biol. 2003;23(2):594-606.
75. Casola A, Henderson A, Liu T, Garofalo RP, Brasier AR. doi: 10.1128/MCB.23.2.594–606.2003
Regulation of RANTES promoter activation in alveolar 82. Leslie K, Song GJ, Barrick S, et al. Ezrin-radixin-moesin-
epithelial cells after cytokine stimulation. Am J Physiol Lung
Cell Mol Physiol. 2002;283:L1280-L1290. binding phosphoprotein 50 (EBP50) and Nuclear Factor-kB
(NFkB). J Biol Chem. 2013;288(51):36426-36436.
doi: 10.1152/ajplung.00162.2002
doi: 10.1074/jbc.M113.483339
76. Hashimoto S, Gon Y, Asai Y, et al. p38 MAP kinase regulates
RANTES production by TNF-alpha-stimulated human 83. Holms R. Pandemics of sexually transmitted infections (STIs):
pulmonary vascular endothelial cells. Allergy. 1999;54:1168-1172. Clinical use of ezrin peptide therapy in Russia to treat and prevent
Candida, Chlamydia, Trichomonas vaginalis, Syphilis, HPV and
doi: 10.1034/j.1398-9995.1999.00224.x Herpes HSV-1 & 2. Microbiol Infect Dis. 2023;7(3):1-21.
77. Lebovic DI, Chao VA, Martini JF, Taylor RN. IL-1β 84. Salamov G, Holms R, Bessler WG, Ataullakhanov R.
Induction of RANTES (Regulated upon Activation, Normal Treatment of hepatitis C virus infection with human
T Cell Expressed and Secreted) chemokine gene expression ezrin peptide one (HEP1) in HIV infected patients.
in endometriotic stromal cells depends on a nuclear Arzneimittelforschung. 2007;57(7):497-504.
factor-kB site in the proximal promoter. J Clin Endocrinol
Metab. 2001;86(10):4759-4764. doi: 10.1055/s-0031-1296637
doi: 10.1210/jcem.86.10.7890 85. Holms RD. Regulatory/Unfolding Peptides of Ezrin. PCT/
GB00/03566, United States Patent US6, 849, 596 B1 issued
78. Song A, Chen YF, Thamatrakoln K, Storm T, Krensky 01.02.2005 Examples 1A, 1B and 3; 2005.
A. RFLAT-1: A New zinc finger transcription factor that
activates RANTES gene expression in T lymphocytes. 86. Chulkina M, Negmadjanovc U, Lebedeva E, et al. Synthetic
Immunity. 1999;10:93-103. peptide TEKKRRETVEREKE derived from ezrin induces
differentiation of NIH/3T3 fibroblasts. Eur J Pharmacol.
doi: 10.1016/S1074-7613(00)80010-2 2017;811:249-259.
79. Nikolcheva T, Pyronnet S, Chou S, et al. A translational doi: 10.1016/j.ejphar.2017.06.033
rheostat for RFLAT-1 regulates RANTES expression in T
lymphocytes. J Clin Invest. 2002;110(1):119-126. 87. Holms RD. Regulatory/Unfolding Peptides of Ezrin. PCT/
GB00/03566, United States Patent US6, 849, 596 B1 issued
doi: 10.1172/JCI15336 01.02.2005 Example 2; 2005.
80. Viswanatha R, Wayt J, Ohouo PY, Smolka MB, Bretscher A. 88. Chulkina MM, Pichugin AV, Ataullakhanov RI. Pharmaceutical
Interactome analysis reveals ezrin can adopt multiple grade synthetic peptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-
conformational states. J Biol Chem. 2013;288(49):35437-35451. Val-Glu-Arg-Glu-Lys-Glu ameliorates DSS-induced murine
doi: 10.1074/jbc.M113.505669 colitis by reducing the number and pro-inflammatory activity
of colon tissue-infiltrating Ly6G+ granulocytes and Ly6C+
81. Estell K, Braunstein G, Tucker T, Varga K, Collawn JF,
Schwiebert LM. Plasma membrane CFTR regulates monocytes. Peptides. 2020;132:170364.
RANTES expression via its C-terminal PDZ-interacting doi: 10.1016/j.peptides.2020.170364
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