Page 106 - MI-1-2

Microbes & Immunity

CASE REPORT
Cedecea lapagei as an emerging extensively

drug-resistant microorganism: A case report in
a patient with pleural empyema and literature

review

1
Bhawna Sharma * ,Jai Ranjan 1 , Akriti Aggarwal 1 , Priyanka Jangra 2 ,
Harmandeep Singh Jabbal 3 , and Kamla Kant 1
1 Department of Microbiology, AIIMS, Bathinda, Punjab, India
2 Department of Microbiology, Agroha Medical College, Hisar, Haryana, India
3 Department of Surgery, AIIMS, Bathinda, Punjab, India

Abstract

Cedecea lapagei is a Gram-negative bacterium that belongs to the Enterobacteriaceae
family and is said to be pathogenic for humans. Herein, we report a case of extensively
drug-resistant C. lapagei in a patient with pleural empyema and offer a literature
review of the already documented case reports on individuals infected with C.
lapagei. A 60-year-old female patient was brought to the emergency department at
AIIMS Bathinda with a history of breathing difficulty since one day after she sustained
multiple injuries from a road accident. She was diagnosed with pleural empyema.
*Corresponding author:
Bhawna Sharma Subsequently, an intercostal drain tube was inserted into the patient, and the drain
(34bhawnasharma@gmail.com) content was sent for culture, which revealed growth of C. lapagei. Our literature
Citation: Sharma B, Ranjan J, retrieval work gathered a total of 13 relevant cases. In conclusion, early identification
Aggarwal A, Jangra P, Jabbal HS, of C. lapagei and administering suitable treatment is important for good patient
Kant K. Cedecea lapagei as an outcome.
emerging extensively drug-resistant
microorganism: A case report in
a patient with pleural empyema
and literature review. Microbes & Keywords: Cedecea lapagei; Intercostal drain; Multidrug resistance
Immunity. 2024;1(2):100-105.
doi: 10.36922/mi.4520
Received: August 14, 2024
1. Background
Accepted: September 24, 2024
Cedecea are Gram-negative bacteria belonging to Enterobacteriaceae family with six
Published Online: October 21, 2024
known species. Among them, Cedecea davisae, Cedecea lapagei, and Cedecea neteri are
1
Copyright: © 2024 Author(s). regarded as human pathogens. Cedecea are catalase-positive, oxidase-negative, motile,
1,2
This is an Open-Access article non-lactose fermenting, non-sporing, and non-encapsulated bacteria that are capable of
distributed under the terms of the
Creative Commons Attribution reducing nitrates to nitrites. First discovered in 1977, it was not recognized as a potential
License, permitting distribution, pathogen to humans until 2006. This bacterium was first described in a 55-year-old man
and reproduction in any medium, with hypertension and a recent history of liver transplant on ambulatory peritoneal dialysis.
provided the original work is
properly cited. He developed peritonitis, and his peritoneal fluid specimen was sent for culture, which
revealed growth of C. lapagei. C. lapagei was further isolated in patients with pneumonia,
1
Publisher’s Note: AccScience
Publishing remains neutral with bacteremia, soft-tissue infection, peritonitis, sepsis, hemoptysis, and urosepsis. 2,3
regard to jurisdictional claims in
published maps and institutional In this paper, we report a case of isolation of C. lapagei, which was extensively drug-
affiliations. resistant, from a patient with pleural empyema after sustaining traumatic chest injuries

Volume 1 Issue 2 (2024) 100 doi: 10.36922/mi.4520